Agomelatine – Powder, 1g

Agomelatine – Powder, 1g

Agomelatine represents a premium, laboratory-grade investigational synthetic antidepressant compound delivered in ultra-pure lyophilized powder form at 1g quantity. This high-purity raw chemical material provides exceptional technical value to modern scientific investigations focused on depression research, sleep quality studies, circadian rhythm regulation analysis, mood enhancement modeling, and melatonin receptor signaling pathways. The lyophilized powder format ensures maximum stability and precise reconstitution accuracy for analytical testing and in vitro/in vivo modeling applications conducted by qualified investigators studying major depressive disorder, insomnia, and sleep-wake cycle disorders.

Our global shipping infrastructure ensures seamless delivery to research facilities worldwide. Domestic orders within the United States ship directly from primary U.S. production facilities, ensuring rapid fulfillment across all 50 states. International orders, including all European countries, utilize our dedicated United Kingdom shipping hub to ensure seamless, efficient customs clearance across the UK and continental Europe, minimizing transit delays while maintaining chemical stability throughout shipment.

• Unique lot-coding on every vessel with public third-party HPLC and mass spectrometry lab reports available for absolute transparency and quality verification

• Formulation completely free of adulterants, excipients, flow agents, or stabilizers to guarantee unadulterated raw chemical purity for accurate research data

• Strategic precision over-weighing inside the vessel compensates for natural adhesion loss during laboratory transfer, ensuring investigators receive minimum labeled quantity

• Packaging engineering utilizes UV-resistant sealing with tamper-proof closure designed specifically for transit safety and structural integrity during international shipment

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

Melatonin Receptor Agonism & 5-HT2C Antagonist Antidepressant Mechanisms

Agomelatine is a novel antidepressant that is structurally closely related to melatonin, functioning as an extremely potent agonist at both melatonin receptors MT1 and MT2, with additional antagonism at serotonin-2C (5-HT2C) receptors. The MT1 and MT2 receptors are known to be involved in sleep quality and circadian rhythm regulation, which are key mechanisms in treating depression and sleep disorders. Agomelatine has been tested in animal models of depression and demonstrates significant antidepressant activity. The compound is used in the treatment of depression in adults, acting through modulation of neurotransmitters in the brain to improve mood and sleep quality, and is often used in cases where patients have insomnia comorbidity. Agomelatine helps improve mood and sleep quality, and is particularly useful for patients with insomnia associated with depression. The dual mechanism of melatonin receptor agonism and 5-HT2C antagonism provides unique benefits over traditional antidepressants, with improved sleep onset and quality, mood improvement, and reduced anxiety symptoms. Research applications include major depressive disorder research, sleep quality and insomnia studies, circadian rhythm regulation investigations, mood enhancement modeling, anxiety reduction research, melatonin receptor signaling analysis, 5-HT2C receptor antagonism studies, antidepressant mechanism research, and sleep-wake cycle disorder investigations.

Handling & Storage Guidelines

• Long-Term Storage: Store at 2-8°C (refrigerated). Keep container tightly closed in a cool, dry place away from heat and light. Protect from moisture and light. Maintain refrigerated storage for optimal stability. Shelf life up to 2 years when stored properly.

• Solubility: Soluble in DMSO and ethanol. Standard laboratory solvents such as DMSO are typically used for in vitro applications. Variable solubility in water depending on formulation.

• Appearance: White to off-white powder, crystals and/or chunks in lyophilized form.

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.