Dihexa – Solution, 300mg (10mg/mL)

Dihexa – Solution, 300mg (10mg/mL)

Dihexa represents a premium, laboratory-grade investigational synthetic oligopeptide delivered in precise liquid solution format at 10mg/mL concentration with 300mg total quantity in 30mL bottle. This high-purity peptide material provides exceptional technical value to modern scientific investigations focused on neuroregeneration research, synaptic plasticity studies, cognitive enhancement analysis, memory improvement modeling, and HGF/c-Met signaling pathways. The liquid solution format at 10mg/mL ensures precise concentration accuracy and eliminates reconstitution variability for analytical testing and in vitro/in vivo modeling applications conducted by qualified investigators studying Alzheimer’s disease, neurological decline, and cognitive deficits. The solution is formulated in DMSO for optimal stability and contains less than 10% variance in concentration, guaranteeing consistency across batches.

Our global shipping infrastructure ensures seamless delivery to research facilities worldwide. Domestic orders within the United States ship directly from primary U.S. production facilities, ensuring rapid fulfillment across all 50 states. International orders, including all European countries, utilize our dedicated United Kingdom shipping hub to ensure seamless, efficient customs clearance across the UK and continental Europe, minimizing transit delays while maintaining chemical stability throughout shipment.

• Unique lot-coding on every vessel with public third-party HPLC and mass spectrometry lab reports available for absolute transparency and quality verification

• Less than 10% variance in concentration, guaranteeing consistency across batches

• Formulation completely free of adulterants, excipients, flow agents, or stabilizers to guarantee unadulterated raw peptide purity for accurate research data

• Includes graduated pipette for convenient and precise measurement

• Glass bottle with UV resistance to minimize degradation during storage

• Tamper-proof seal to ensure safety in transit

• Packaging engineering utilizes formulation designed to prevent evaporation in storage

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

HGF/c-Met Agonist & Angiotensin IV-Derived Neuroregeneration Mechanisms

Dihexa (PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a novel, potent, oral, brain-permeable oligopeptide drug derived from angiotensin IV that binds with high affinity (Kd = 65 pM) to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. Dihexa is an orally active, blood-brain barrier (BBB) permeable analog of angiotensin IV, categorized as a nootropic compound with long cyclical half-life and potential to promote anti-dementia activity. Dihexa has been shown to be up to seven orders of magnitude more potent than brain-derived neurotrophic factor (BDNF) in neurotrophic activity assays, demonstrating exceptional neurotrophic potency. Dihexa improves cognition and increases synapses in rat models of cognitive dysfunction, making it valuable for neurodegenerative disease research. Dihexa has demonstrated excellent antipsychotic activity as well as improvement in cognitive function in animal models, and exhibits excellent antidementia activity. Dihexa (PNB-0408) restored AngIV decline in APP/PS1 mice, saved the cognitive function of mice, improved neuronal loss in mice and reduced neuroinflammation. Dihexa has potential for the study of Alzheimer’s disease and may have therapeutic potential as a treatment for Alzheimer’s disease. In in vitro studies, Dihexa was analyzed to protect auditory cells from aminoglycoside toxicity, indicating its potential neuroprotective properties. Research applications include neuroregeneration research, synaptic plasticity studies, cognitive enhancement investigations, memory improvement modeling, Alzheimer’s disease research, neurological decline studies, HGF/c-Met signaling analysis, neurogenesis research, antipsychotic activity studies, antidementia activity research, and auditory cell neuroprotection investigations.

Handling & Storage Guidelines

• Long-Term Storage: Store at -20°C (freezer). Keep container tightly sealed away from heat, light and moisture. Protect from moisture and light. Avoid repeated freeze-thaw cycles. For solvent storage, do not recommend long-term storage — use soon. Do NOT freeze once reconstituted (though this solution is already in DMSO). Shelf life up to 2 years when stored properly.

• Solubility: Soluble only in DMSO (100 mg/mL = 198.15 mM). Insoluble in water and ethanol. Due to hydrophobic nature, Dihexa does not dissolve in pure water and must be mixed with suitable solvent such as DMSO. Adding water may cause solution to become cloudy. Ultrasonic treatment for 2 seconds typically clears the solution. Includes graduated pipette for convenient measurement.

• Concentration: 10mg/mL ±10% (300mg total in 30mL/1 fl oz bottle).

• Appearance: Clear solution in glass vial with UV resistance.

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.