Dihexa – Powder, 500mg

Dihexa – Powder, 500mg

Dihexa represents a premium, laboratory-grade investigational synthetic oligopeptide delivered in ultra-pure lyophilized powder form at 500mg quantity. This high-purity peptide material provides exceptional technical value to modern scientific investigations focused on neuroregeneration research, synaptic plasticity studies, cognitive enhancement analysis, memory improvement modeling, and HGF/c-Met signaling pathways. The lyophilized peptide format ensures maximum stability and precise reconstitution accuracy for analytical testing and in vitro/in vivo modeling applications conducted by qualified investigators studying Alzheimer’s disease, neurological decline, and cognitive deficits.

Our global shipping infrastructure ensures seamless delivery to research facilities worldwide. Domestic orders within the United States ship directly from primary U.S. production facilities, ensuring rapid fulfillment across all 50 states. International orders, including all European countries, utilize our dedicated United Kingdom shipping hub to ensure seamless, efficient customs clearance across the UK and continental Europe, minimizing transit delays while maintaining chemical stability throughout shipment.

• Unique lot-coding on every vessel with public third-party HPLC and mass spectrometry lab reports available for absolute transparency and quality verification

• Formulation completely free of adulterants, excipients, flow agents, or stabilizers to guarantee unadulterated raw peptide purity for accurate research data

• Strategic precision over-weighing inside the vessel compensates for natural adhesion loss during laboratory transfer, ensuring investigators receive minimum labeled quantity

• Packaging engineering utilizes UV-resistant sealing with tamper-proof closure designed specifically for transit safety and structural integrity during international shipment

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

HGF/c-Met Agonist & Angiotensin IV-Derived Neuroregeneration Mechanisms

Dihexa (PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a novel, potent, oral, brain-permeable oligopeptide drug derived from angiotensin IV that binds with high affinity (Kd = 65 pM) to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. Dihexa is a synthetic compound engineered for laboratory investigation of molecular pathways with research indicating specific activity in protein-protein interaction studies and cellular signaling mechanisms. Dihexa peptide is an orally active, blood-brain barrier (BBB) permeable oligopeptide derived from Angiotensin IV, engineered for investigation into synaptic plasticity and neuroregeneration. By acting as a potent agonist of the Hepatocyte Growth Factor (HGF) and its receptor, c-Met, Dihexa is studied for its potential to facilitate the formation of new functional synaptic connections in experimental models of neurological decline. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor (BDNF), demonstrating exceptional neurotrophic potency. Dihexa has been found to potently improve cognitive function in animal models of Alzheimer’s disease-like mental impairment, making it valuable for neurodegenerative disease research. The compound has been shown to possess a wide range of biological activities, including enhancing cognitive function, promoting neurogenesis, and potentially mitigating the effects of neurodegenerative diseases. Research applications include neuroregeneration research, synaptic plasticity studies, cognitive enhancement investigations, memory improvement modeling, Alzheimer’s disease research, neurological decline studies, HGF/c-Met signaling analysis, neurogenesis research, BDNF pathway comparison studies, and neuroprotection investigations.

Handling & Storage Guidelines

• Long-Term Storage: Store at -20°C for powder (3 years from date of receipt). For ambient storage: store at 4°C (2 years). For solvent storage: -80°C for 6 months, -20°C for 1 month. Alternatively, store at room temperature, tightly sealed, away from heat, light and moisture. Keep container tightly closed in a dry, cool place. Protect from moisture and light. UV protective matte black sealed bag packaging.

• Solubility: Soluble in DMSO and PEG400. Standard laboratory solvents such as DMSO are typically used for in vitro applications.

• Appearance: White lyophilized powder in sealed container.

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.