HBT1 – Powder, 1g

HBT1 – Powder, 1g

This premium laboratory-grade research compound is supplied as ultra-pure raw lyophilized powder with white to beige crystalline appearance, engineered for modern scientific investigations requiring precise AMPA receptor pharmacology and neurotrophic factor modulation. HBT1 (YDL223C) is a novel AMPA receptor potentiator that specifically binds to the ligand-binding domain (LBD) of AMPAR in glutamate-dependent manner, enhancing receptor activity and inducing BDNF production while exhibiting little agonistic effect in primary neurons, making it a valuable tool for in vitro/in vivo modeling of synaptic plasticity, cognitive enhancement, neurodegenerative disease research, and neurological function studies.

All domestic orders ship directly from primary United States production facilities, ensuring rapid delivery to all 50 U.S. states. International orders to the UK and continental Europe are fulfilled through our dedicated United Kingdom shipping hub, enabling seamless, efficient customs clearance across European borders without delay.

• Lot-coded containers with publicly accessible third-party HPLC/LC-MS lab reports verifying specification ≥99% purity for absolute transparency

• Formulation completely free of adulterants, excipients, and flow agents to guarantee raw chemical purity

• Strategic over-weighing inside the vessel compensates for natural adhesion loss during laboratory transfer

• Packaging engineering utilizes a glass vial with tamper-proof seal to maintain chemical stability during transit

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

AMPA Receptor Potentiator with BDNF Induction Profile

HBT1 (YDL223C) functions as a potent and selective α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator that specifically binds to the ligand-binding domain (LBD) of AMPAR in glutamate-dependent manner, enhancing receptor activity and inducing production of brain-derived neurotrophic factor (BDNF). In patch-clamp study using primary neurons, HBT1 showed little agonistic effect whereas comparator compounds LY451395 and OXP1 showed remarkable agonistic effects, establishing HBT1 as an AMPA-R potentiator with lower agonistic effects ideal for research requiring enhanced receptor modulation without excessive neuronal activation. This unique mechanism makes HBT1 valuable for investigators studying synaptic plasticity, learning and memory enhancement, cognitive performance, neurodegenerative diseases (including Alzheimer’s disease), neurological function, neurotrophic factor modulation, and comparative pharmacology of AMPA receptor potentiators in in vitro and in vivo experimental models.

Handling & Storage Guidelines

• Long-Term Storage: Store powder at -20°C for up to 3 years; following reconstitution, aliquot and freeze at -80°C; stock solutions stable for up to 1 year at -80°C; Sigma-Aldrich recommends 2–8°C storage

• Solubility: DMSO: 3.87 mg/mL (10.02 mM), sonication recommended; DMSO: 2 mg/mL clear; soluble in DMSO

• Appearance: White to beige crystalline powder with predicted relative density 1.58 g/cm³

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.