Sarcosine – Powder, 50g

Sarcosine – Powder, 50g

This premium, laboratory-grade research compound delivers ultra-pure raw N-methylglycine powder at ≥98% purity, representing the highest standard for modern scientific investigations into glutamatergic neurotransmission and glycine transporter mechanisms. The lyophilized crystalline powder form provides investigators with a single-compound reference standard ideal for analytical testing, in vitro neuronal cell culture modeling, and in vivo preclinical research applications where precise sarcosine isolation is critical for studying NMDA receptor co-activation and glycine transporter inhibition.

All shipments to the 50 United States are fulfilled directly from primary U.S. production facilities, ensuring 2-5 business day delivery nationwide. International orders to the United Kingdom and continental Europe are processed through our dedicated United Kingdom shipping hub, which streamlines customs clearance and reduces transit times across all European countries. This dual-hub logistics infrastructure guarantees seamless, compliant delivery while maintaining chemical integrity throughout transit.

• Public third-party lab reports with unique lot-coding ensure absolute transparency for every batch sold

• Formulation contains zero adulterants, excipients, flow agents, or contaminants—pure sarcosine only

• Strategic over-weighing compensates for powder adhesion loss, guaranteeing minimum 50g recoverable material

• PET single-wall jar features UV-resistant construction and tamper-proof seal for transit safety

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

GlyT1 Inhibition & NMDA Receptor Co-Agonism Profile

Sarcosine functions as a potent competitive inhibitor of the type I glycine transporter (GlyT1), blocking glycine reuptake at presynaptic terminals and increasing extracellular glycine concentrations available for NMDA receptor activation. As an NMDA receptor co-agonist, sarcosine binds the glycine site on the GluN1 subunit, enhancing NMDAR signaling without producing full agonism—this mechanism is particularly valuable for studying NMDA hypofunction implicated in schizophrenia pathophysiology. Sarcosine also exhibits weak partial agonist activity at glycine receptors (GlyR), though with lower potency than glycine itself. In vivo models demonstrate weak anticonvulsant properties and amelioration of prepulse inhibition (PPI) deficits in mGluR5 knockout mice, supporting its utility in neuropsychiatric research. A groundbreaking 2025 study revealed sarcosine-15N’s role in amplifying ferroptosis in lung adenocarcinoma models by binding the BCDHK_Adom3 domain of pyruvate dehydrogenase kinase 4 (PDK4), enhancing PDH activity by 60% and shifting metabolism toward oxidative phosphorylation.

Handling & Storage Guidelines

• Long-Term Storage: Store desiccated at room temperature (15-25°C) in airtight conditions; avoid moisture exposure (pKa₁ = 2.2, pKa₂ = 10.1, zwitterionic in aqueous solutions)

• Solubility: Soluble in water (50 mg/mL, ~5.6%); soluble in DMSO (20 mg/mL); slightly soluble in ethanol; forms clear solutions in aqueous buffers

• Appearance: Fine white crystalline powder with zwitterionic behavior in aqueous solutions

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.