SR9009 – Powder, 1g

SR9009 – Powder, 1g

SR9009 represents a premium, laboratory-grade investigational Rev-erbα/β agonist delivered in ultra-pure lyophilized powder form at 1g quantity. This high-purity raw chemical material provides exceptional technical value to modern scientific investigations focused on circadian biology, metabolic disorder research, lipid metabolism analysis, and cardiovascular preclinical studies. The lyophilized powder format ensures maximum stability and precise reconstitution accuracy for analytical testing and in vitro/in vivo modeling applications conducted by qualified investigators studying metabolic pathways and circadian rhythm disruption.

Our global shipping infrastructure ensures seamless delivery to research facilities worldwide. Domestic orders within the United States ship directly from primary U.S. production facilities, ensuring rapid fulfillment across all 50 states. International orders, including all European countries, utilize our dedicated United Kingdom shipping hub to ensure seamless, efficient customs clearance across the UK and continental Europe, minimizing transit delays while maintaining chemical stability throughout shipment.

• Unique lot-coding on every vessel with public third-party HPLC and mass spectrometry lab reports available for absolute transparency and quality verification

• Formulation completely free of adulterants, excipients, flow agents, or stabilizers to guarantee unadulterated raw chemical purity for accurate research data

• Strategic precision over-weighing inside the vessel compensates for natural adhesion loss during laboratory transfer, ensuring investigators receive minimum labeled quantity

• Packaging engineering utilizes UV-resistant sealing with tamper-proof closure designed specifically for transit safety and structural integrity during international shipment

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

Rev-erbα/β Agonist Activity & Circadian-Metabolic Pathway Regulation

SR9009 functions as a potent synthetic agonist of the nuclear receptors REV-ERBα and REV-ERBβ, which are core clock components linking circadian rhythms to metabolic regulation. The compound increases the constitutive repression of genes regulated by REV-ERBα/ERBβ with IC50 values of 670 nM and 800 nM respectively, demonstrating dose-dependent increases in REV-ERB-dependent repressor activity at concentrations of 0.01-10 nM in HEK293 cells. SR9009 suppresses BMAL1 mRNA expression in HepG2 cells in a REV-ERBα/β-dependent manner and inhibits adipogenesis in 3T3-L1 cells. Research applications include circadian rhythm disruption modeling, metabolic syndrome research, lipid metabolism studies, insulin resistance investigations, obesity research, cardiovascular function improvement, and exercise ability/glycolipid metabolism regulation.

Handling & Storage Guidelines

• Long-Term Storage: Store in a cool, dry place at room temperature or refrigerated (2-8°C), minimizing open air exposure. Keep in desiccated environment protected from moisture and light.

• Solubility: Soluble in DMSO. Stock solution typically prepared according to experimental requirements for in vitro applications.

• Appearance: Lyophilized powder, white to off-white crystalline solid form.

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.