GW0742 – Powder, 1g

GW0742 – Powder, 1g

This premium, laboratory-grade research compound delivers ultra-pure raw GW0742 powder at ≥98% purity, representing the highest standard for modern scientific investigations into PPARδ/β receptor activation and metabolic regulation mechanisms. The lyophilized crystalline powder form provides investigators with a single-compound reference standard ideal for analytical testing, in vitro cell culture modeling of metabolic pathways, and in vivo preclinical research applications where precise GW0742 isolation is critical for studying lipid metabolism enhancement, fatty acid oxidation, and glucose homeostasis.

All shipments to the 50 United States are fulfilled directly from primary U.S. production facilities, ensuring 2-5 business day delivery nationwide. International orders to the United Kingdom and continental Europe are processed through our dedicated United Kingdom shipping hub, which streamlines customs clearance and reduces transit times across all European countries. This dual-hub logistics infrastructure guarantees seamless, compliant delivery while maintaining chemical integrity throughout transit.

• Public third-party lab reports with unique lot-coding ensure absolute transparency for every batch sold

• Formulation contains zero adulterants, excipients, flow agents, or contaminants—pure GW0742 only

• Strategic over-weighing compensates for powder adhesion loss, guaranteeing minimum 1g recoverable material

• PET single-wall jar features UV-resistant construction and tamper-proof seal for transit safety

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

PPARδ Agonism & Lipid Metabolism Enhancement Profiling

GW0742 (GW-0742, GW610742, Fitorine) functions as a synthetic, potent, and highly selective PPARβ/δ agonist developed by GlaxoSmithKline, representing one of the most selective PPARδ agonists available for research. The compound is a potent PPARβ and PPARδ agonist with an EC₅₀ of 1 nM for human PPARδ and an IC₅₀ of 1 nM in binding assays, demonstrating approximately 1000-fold selectivity over PPARα (EC₅₀ = 1.1 μM) and PPARγ (EC₅₀ = 2 μM). GW0742 activates fatty acid beta-oxidation pathways and enhances lipid metabolism, improving glucose homeostasis through PPARδ-mediated transcriptional regulation. Interestingly, GW0742 functions as a dual PPAR-β agonist and antagonist depending on the dosage administered, with weak activity on multiple nuclear receptors and antagonistic effects at androgen receptors and vitamin D receptor (VDR). The compound has been shown to ameliorate experimentally induced pancreatitis in mice, demonstrating therapeutic potential for inflammatory conditions. Additionally, GW0742 prevents hypertension in diet-induced obese mice and has been investigated as a potential antidiabetic drug due to its anti-inflammatory effects and metabolic regulation capabilities. The compound increases HDL cholesterol and promotes orange adipose tissue browning, contributing to improved metabolic health and lipid metabolism. This PPARδ agonist mechanism positions GW0742 as a critical tool compound for investigating obesity research, metabolic syndrome studies, diabetes mechanisms, cardiovascular disease pathways, inflammation research, pancreatitis models, hypertension in obese populations, and lipid metabolism regulation in preclinical models, offering potential therapeutic insights for metabolic disorders.

Handling & Storage Guidelines

• Long-Term Storage: Store at -20°C (-4°F) for optimal stability (up to 3 years); stable at room temperature for short-term storage. Protect from light and moisture; store in a cool, dry place in airtight conditions; melting point: 134.5-135.5°C

• Solubility: DMSO: 250 mg/mL (530.23 mM), sonication recommended; >5 mg/mL in DMSO; Ethanol: soluble; Water: insoluble (<1 mg/mL); DMF: 25 mg/mL; In Vivo formulation: 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline at 2 mg/mL (4.24 mM), sonication recommended, dissolve by heating/sonication if necessary

• Appearance: White crystalline powder; clear solutions in DMSO and ethanol; insoluble in aqueous solutions

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.