Cardarine (GW501516) – Solution, 600mg (20mg/mL)

Cardarine (GW501516) – Solution, 600mg (20mg/mL)

This premium, laboratory-grade research compound delivers ultra-pure Cardarine solution at 20mg/mL concentration in PEG400/Ethanol carrier, representing the highest standard for modern scientific investigations into PPARδ receptor activation and lipid metabolism regulation mechanisms. The ready-to-use solution format eliminates preparation time and ensures precise dosing accuracy for in vivo animal studies, eliminating solubility variability (GW501516 is insoluble in water) and providing investigators with a validated vehicle system ideal for analytical testing, pharmacokinetic modeling, and in vivo preclinical research applications where precise Cardarine administration is critical for studying fatty acid oxidation enhancement, mitochondrial biogenesis, and exercise-mimetic pathways.

All shipments to the 50 United States are fulfilled directly from primary U.S. production facilities, ensuring 2-5 business day delivery nationwide. International orders to the United Kingdom and continental Europe are processed through our dedicated United Kingdom shipping hub, which streamlines customs clearance and reduces transit times across all European countries. This dual-hub logistics infrastructure guarantees seamless, compliant delivery while maintaining chemical integrity throughout transit.

• Public third-party lab reports with unique lot-coding ensure absolute transparency for every batch sold

• Formulation contains zero adulterants, excipients, flow agents, or contaminants—pure Cardarine in PEG400/Ethanol only

• Strategic over-fill compensates for solution adhesion loss, guaranteeing minimum 30mL (600mg) recoverable volume

• Amber glass bottle features UV-resistant construction and tamper-proof seal for transit safety

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

PPARδ Agonism & Lipid Metabolism Enhancement Profiling

Cardarine (GW501516, GW-501516, Endurobol) functions as a potent and highly selective peroxisome proliferator-activated receptor delta (PPARβ/δ) agonist with an EC₅₀ of 1 nM and Ki of 1 nM for PPARδ, demonstrating greater than 1000-fold selectivity over PPARα and PPARγ subtypes. The compound acts as a ligand-activated transcription factor, binding to receptors in skeletal muscle and adipose tissue, recruiting the coactivator PGC-1α to form a complex that enhances expression of proteins involved in energy expenditure and fatty acid oxidation. GW501516 dramatically increases serum high-density lipoprotein (HDL) cholesterol by up to 50% while lowering levels of small-dense low-density lipoprotein (LDL) by up to 25%, reducing fasting triglycerides and free fatty acids, demonstrating profound effects on lipid metabolism and cardiovascular risk factors. By activating AMP-activated protein kinase (AMPK), Cardarine enhances fatty acid oxidation and fat loss, reduces inflammation, improves insulin sensitivity and glucose tolerance, and increases endurance and stamina. Investigated as a potential treatment for obesity, diabetes, dyslipidemia, and cardiovascular disease due to its profound metabolic effects, GW501516 was developed through a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s. The compound has been demonstrated to activate some of the same pathways activated through exercise, making it an exercise mimetic agent that enhances endurance capacity. However, GW501516 showed increased cancer incidence in multiple organs in rats during long-term toxicity studies at high doses (3mg/kg/day), leading to discontinuation of human clinical development, making it primarily a research tool compound rather than a therapeutic candidate. This PPARδ agonist mechanism positions Cardarine solution as a critical tool compound for investigating lipid metabolism research, dyslipidemia models, obesity studies, diabetes mechanisms, cardiovascular disease pathways, and exercise-mimetic metabolic regulation in preclinical models, offering potential therapeutic insights for metabolic disorders.

Handling & Storage Guidelines

• Long-Term Storage: Store at room temperature (20-25°C) in a cool, dry place away from direct sunlight to maintain potency and maximize shelf life (up to 2 years). UV-resistant glass bottle minimizes degradation; tamper-proof seal ensures secure delivery. Avoid excessive heat and moisture

• Solubility: Pre-dissolved in PEG400/Ethanol carrier at 20mg/mL; soluble in DMSO (91 mg/mL), Ethanol (22 mg/mL), and Propylene Glycol/PEG 400; insoluble in water; shake/agitate bottle before each administration for consistency

• Appearance: Clear colorless to pale yellow liquid solution; 30mL volume containing 600mg total Cardarine at 20mg/mL concentration; <5% concentration variance for consistency

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.