MK-677 (Ibutamoren Mesylate) – Solution, 750mg (25mg/mL)

MK-677 (Ibutamoren Mesylate) – Solution, 750mg (25mg/mL)

This premium, laboratory-grade research compound delivers ultra-pure MK-677 (Ibutamoren Mesylate) solution at 25mg/mL concentration, representing the highest standard for modern scientific investigations into ghrelin receptor agonism and growth hormone secretion mechanisms. The ready-to-use solution format eliminates preparation time and ensures precise dosing accuracy for in vivo animal studies, eliminating solubility variability and providing investigators with a validated vehicle system ideal for analytical testing, pharmacokinetic modeling, and in vivo preclinical research applications where precise MK-677 administration is critical for studying GH/IGF-1 elevation and anabolic effects.

All shipments to the 50 United States are fulfilled directly from primary U.S. production facilities, ensuring 2-5 business day delivery nationwide. International orders to the United Kingdom and continental Europe are processed through our dedicated United Kingdom shipping hub, which streamlines customs clearance and reduces transit times across all European countries. This dual-hub logistics infrastructure guarantees seamless, compliant delivery while maintaining chemical integrity throughout transit.

• Public third-party lab reports with unique lot-coding ensure absolute transparency for every batch sold

• Formulation contains zero flow agents, excipients, or adulterants—pure MK-677 solution only

• Strategic over-fill compensates for solution adhesion loss, guaranteeing minimum 30mL (750mg) recoverable volume

• Amber glass bottle features UV-resistant construction and tamper-proof seal for transit safety

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

GHSR Agonism & GH/IGF-1 Elevation Profiling

Ibutamoren (INN; developmental code MK-677, MK-0677, LUM-201, L-163,191; former tentative brand name Oratrope) functions as a potent, long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. The compound stimulates the secretion of several hormones including GH and insulin-like growth factor 1 (IGF-1), and produces sustained increases in the plasma levels of these hormones while also raising cortisol levels. MK-677 is a small molecule that stimulates the production of human growth hormone (hGH) and insulin-like growth factor 1 (IGF-1), with effects similar to peptides that increase hGH levels, but MK-677 can be taken orally as a powder, tablet, or liquid, whereas peptides need to be injected. The increases in hGH and IGF-1 levels cause changes in body composition, such as muscle growth, but these gains aren’t permanent, and effects wear off when people stop taking the drug. In a small study of 14 subjects, ibutamoren dosed at 25 mg/day at bedtime was shown to increase rapid eye movement (REM) sleep by 20% in young subjects and 50% in older subjects, and treatment with ibutamoren also resulted in an approximate 50% increase in slow-wave sleep in young subjects, demonstrating potential sleep quality benefits. MK-677 produced a peak GH response of 55.9 ± 31.7 micrograms/L after single dose (day 1 of treatment) and 22.6 ± 9.3 micrograms/L after a week of dosing, and was generally well tolerated and without clinically significant adverse experiences at 25 mg/day dose. In conclusion, MK-677 reverses diet-induced nitrogen wasting, suggesting that if these short-term anabolic effects are maintained in patients who are catabolic because of certain acute or chronic disease states, it may be useful in treating catabolic conditions, demonstrating its potential for frailty and growth hormone deficiency research. Researchers stopped at least one clinical trial of MK-677 early because of concerns that it might cause heart failure, and the FDA lists Ibutamoren as an ingredient that “poses significant safety risks due to the potential for congestive heart failure in certain patients”. Many studies show diabetes-like impacts of MK-677 including increases in blood glucose levels, reductions in insulin sensitivity and increases in glycated haemoglobin (HbA1c), and it can also affect bone mineral density, representing significant health risks associated with use. MK-677 has been around since the mid-1990s, but it’s still considered an experimental drug, with researchers trialing it for treating frailty in older people and children with growth hormone deficiency, but there are no approved uses for the drug, and MK-677 is banned in sport. MK-677 is on the DoD Prohibited Dietary Supplement Ingredients List and the World Anti-Doping Agency Prohibited List, is not legal for use, and is detectable in blood samples and urine tests with a detection window varying depending on dosage, duration of use and metabolism but can be up to several weeks. Other side effects include anxiety, diarrhea, increased fluid retention and swelling, increased hunger, muscle or joint pain, numbness, and nausea, and the health effects of long-term use have not been investigated and should not be assumed to be safe. This GHSR agonist mechanism positions MK-677 solution as a critical tool compound for investigating GH/IGF-1 elevation research, muscle growth mechanisms, body composition studies, sleep quality enhancement models, frailty in older people models, growth hormone deficiency research, nitrogen wasting reversal, catabolic conditions treatment, and anabolic effects in preclinical models, though with significant safety concerns that limit therapeutic potential.

Handling & Storage Guidelines

• Long-Term Storage: Store at 2-8°C (39°F) in a sealed container, away from light and moisture to maintain potency and maximize shelf life (up to 2 years). UV-resistant glass bottle minimizes degradation; tamper-proof seal ensures secure delivery. Avoid excessive heat and moisture; do not recommend long-term storage for solutions—use promptly after opening

• Solubility: Pre-dissolved formulation ready for direct use; H₂O: 5 mg/mL, clear; DMSO: soluble; Ethanol: soluble; DMF: soluble; for in vivo studies: appropriate vehicle formulation recommended; shake/agitate bottle before each administration for consistency

• Appearance: Clear colorless to pale yellow liquid solution; 30mL volume containing 750mg total MK-677 at 25mg/mL concentration; <5% concentration variance for consistency

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.