GTS-21 HCl – Powder, 5g

GTS-21 HCl – Powder, 5g

This premium laboratory-grade research compound is supplied as ultra-pure raw lyophilized powder with bright yellow to yellow crystalline appearance, engineered for modern scientific investigations requiring precise α7 nicotinic acetylcholine receptor pharmacology. GTS-21 (DMXBA, DMBX-A) is an investigational derivative of anabaseine that acts as a partial agonist selectively binding to both α4β2 and α7 nAChR subtypes but activating only the α7 subtype significantly, demonstrating neuroprotective effects and cognition-enhancing activities valuable for in vitro/in vivo modeling of neurodegenerative diseases, psychiatric disorders, and memory enhancement research.

All domestic orders ship directly from primary United States production facilities, ensuring rapid delivery to all 50 U.S. states. International orders to the UK and continental Europe are fulfilled through our dedicated United Kingdom shipping hub, enabling seamless, efficient customs clearance across European borders without delay.

• Lot-coded containers with publicly accessible third-party HPLC analytical reports verifying absolute purity for absolute transparency

• Formulation completely free of adulterants, excipients, and flow agents to guarantee raw chemical purity

• Strategic over-weighing inside the vessel compensates for natural adhesion loss during laboratory transfer

• Packaging engineering utilizes a glass vial with UV resistance and tamper-proof seal to maintain chemical stability during transit and protect from light degradation

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

α7 Nicotinic Acetylcholine Receptor (α7-nAChR) Partial Agonist Profile

GTS-21 (DMXBA, DMBX-A) functions as a selective partial agonist at α7 nicotinic acetylcholine receptors with EC₅₀ = 10 µM, representing an investigational derivative of the natural product anabaseine that binds to both α4β2 and α7 nAChR subtypes but activates only the α7 subtype to any significant extent. Activation of the α7 nAChR has been shown to produce neuroprotective effects, making GTS-21 a focus of research in treating neurological diseases including Alzheimer’s disease, schizophrenia, ADHD, autism, and nicotine dependence. GTS-21 stimulates dopamine release from rat striatal slices (EC₅₀ = 10 μM) and in vivo decreases delay in the delayed matching-to-sample task in monkeys, demonstrating statistically significant enhancement of attention, working memory, and episodic secondary memory compared to placebo in healthy adult men, establishing its nootropic effect and potential for dementia treatment.

Handling & Storage Guidelines

• Long-Term Storage: Store at −20°C; protect from light; OK to freeze; following reconstitution, aliquot and freeze at -20°C; stock solutions stable for up to 3 months at -20°C

• Solubility: Soluble in DMSO (100 mM); soluble in water (100 mM); standard aqueous and organic solvent compatibility for dihydrochloride salt form

• Appearance: Bright yellow to deep yellow crystalline powder with melting point 216–217°C (decomposition)

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.