NSI-189 Free Base – Powder, 1g

NSI-189 Free Base – Powder, 1g

This premium laboratory-grade research neurogenic compound is supplied as ultra-pure white crystalline powder engineered for modern scientific investigations requiring precise neurogenic small molecule pharmacology and neurogenesis/antidepressant research. NSI-189 (NeuralStem Inc-189, Amdiglurax, ALTO-100, NSI-189 Free Base) is a benzylpiperazine-aminopyridine compound known for its interaction with neurogenic and neurotrophic pathways, structurally classified as a pyridine-based small molecule with high lipophilicity contributing to molecular stability and bioavailability, that promotes proliferation and differentiation of neural stem/progenitor cells, increases hippocampal volume and neurogenesis, exhibits antidepressant effects in major depressive disorder (phase 1b placebo-controlled double-blind trial with 24 patients showed positive changes during drug period and follow-up days using 40mg, 80mg, 120mg per day with 40mg single dose, active in bodies about 17.4–20.5 hours, no side effects at lower doses), undergoes hepatic metabolism via oxidation and conjugation with primary clearance through renal and biliary excretion, has been used for treating post-traumatic stress disorder (PTSD), Alzheimer’s disease and age-related cognitive problems, is a novel neurogenic compound independent of monoamine reuptake pathways (phase 2 double-blind placebo-controlled study evaluated oral NSI-189 as monotherapy in major depressive disorder), reputation as ’emotional enhancer/increaser’ with tendency to skew towards childlike mindset, making it a valuable tool for in vitro/in vivo modeling of neurogenesis stimulation, antidepressant research, major depressive disorder, neurotrophic pathway modulation, hippocampal volume enhancement, PTSD, Alzheimer’s disease, age-related cognitive problems, and neurogenic small molecule pharmacology research.

All domestic orders ship directly from primary United States production facilities, ensuring rapid delivery to all 50 U.S. states. International orders to the UK and continental Europe are fulfilled through our dedicated United Kingdom shipping hub, enabling seamless, efficient customs clearance across European borders without delay.

• Lot-coded containers with publicly accessible third-party HPLC lab reports verifying specification ≥99% purity for absolute transparency

• Formulation completely free of adulterants, excipients, and flow agents to guarantee raw chemical purity

• Strategic crystallization stabilizes compound structure for long-term storage and maintains integrity during transit

• Packaging engineering utilizes a glass jar with tamper-proof seal to maintain powder stability during transit and cool dry place storage

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

Neurogenic Small Molecule with Hippocampal Volume Enhancement and Antidepressant Profile

NSI-189 functions as a benzylpiperazine-aminopyridine compound, structurally classified as a pyridine-based small molecule with high lipophilicity contributing to molecular stability and bioavailability, interacting with neurogenic and neurotrophic pathways. The compound demonstrates neurogenic small molecule that promotes proliferation and differentiation of neural stem/progenitor cells, increases hippocampal volume and neurogenesis, exhibits antidepressant effects in major depressive disorder with phase 1b placebo-controlled double-blind trial showing positive changes using 40mg, 80mg, 120mg per day (40mg single dose, active 17.4–20.5 hours, no side effects at lower doses), is novel neurogenic compound independent of monoamine reuptake pathways with phase 2 study evaluating oral NSI-189 as monotherapy in major depressive disorder, undergoes hepatic metabolism via oxidation and conjugation with primary clearance through renal and biliary excretion, has been used for treating PTSD, Alzheimer’s disease and age-related cognitive problems, reputation as emotional enhancer/increaser with tendency to skew towards childlike mindset, making it valuable for investigators studying neurogenesis stimulation, antidepressant research, major depressive disorder, neurotrophic pathway modulation, hippocampal volume enhancement, PTSD, Alzheimer’s disease, age-related cognitive problems, and neurogenic small molecule pharmacology in in vitro and in vivo experimental models.

Handling & Storage Guidelines

• Long-Term Storage: Store in cool dry place, tightly sealed, away from heat, light and moisture; crystalline powder stable in cool dry place; store container tightly closed in dry, cool place

• Solubility: Soluble in DMSO at 10 mM; white crystalline powder appearance

• Appearance: White crystalline powder, solid form

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. Always consult with a healthcare professional before starting any new supplement or research product. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.