NSI-189 Free Base – Solution, 1200mg (40mg/mL)

NSI-189 Free Base – Solution, 1200mg (40mg/mL)

This premium laboratory-grade research neurogenic compound is supplied as a ready-to-use solution engineered for modern scientific investigations requiring precise neurogenic small molecule pharmacology and neurogenesis/antidepressant research. NSI-189 (NeuralStem Inc-189, Amdiglurax, ALTO-100, NSI-189 Free Base) is a benzylpiperazine-aminopyridine compound known for its interaction with neurogenic and neurotrophic pathways, structurally classified as a pyridine-based small molecule with high lipophilicity contributing to molecular stability and bioavailability, that promotes proliferation and differentiation of neural stem/progenitor cells, increases hippocampal volume and neurogenesis, exhibits antidepressant effects in major depressive disorder (phase 1b placebo-controlled double-blind trial with 24 patients showed positive changes during drug period and follow-up days using 40mg, 80mg, 120mg per day with 40mg single dose, active in bodies about 17.4–20.5 hours, no side effects at lower doses), undergoes hepatic metabolism via oxidation and conjugation with primary clearance through renal and biliary excretion, has been studied as potential treatment for post-traumatic stress disorder (PTSD), Alzheimer’s disease and age-related cognitive problems, is a novel neurogenic compound independent of monoamine reuptake pathways (phase 2 double-blind placebo-controlled study evaluated oral NSI-189 as monotherapy in major depressive disorder where 40mg dose resulted in significantly greater symptom reduction), reputation as ’emotional enhancer/increaser’ with tendency to skew towards childlike mindset, making it a valuable tool for in vitro/in vivo modeling of neurogenesis stimulation, antidepressant research, major depressive disorder, neurotrophic pathway modulation, hippocampal volume enhancement, PTSD, Alzheimer’s disease, age-related cognitive problems, and neurogenic small molecule pharmacology research.

All domestic orders ship directly from primary United States production facilities, ensuring rapid delivery to all 50 U.S. states. International orders to the UK and continental Europe are fulfilled through our dedicated United Kingdom shipping hub, enabling seamless, efficient customs clearance across European borders without delay.

• Batch-coded containers with publicly accessible third-party lab reports verifying specification consistency for absolute transparency

• Formulation completely free of adulterants, excipients, and stabilizers to guarantee raw chemical purity in solution

• Packaging engineering utilizes a glass bottle with UV resistance and tamper-proof seal to maintain solution stability during transit and cool dry place storage

• Includes graduated pipette for convenient measurement; less than 10% variance in concentration guarantees consistency

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

Neurogenic Small Molecule with Hippocampal Volume Enhancement and Antidepressant Profile

NSI-189 functions as a benzylpiperazine-aminopyridine compound, structurally classified as a pyridine-based small molecule with high lipophilicity contributing to molecular stability and bioavailability, interacting with neurogenic and neurotrophic pathways. The compound demonstrates neurogenic small molecule that promotes proliferation and differentiation of neural stem/progenitor cells, increases hippocampal volume and neurogenesis, exhibits antidepressant effects in major depressive disorder with phase 1b placebo-controlled double-blind trial showing positive changes using 40mg, 80mg, 120mg per day (40mg single dose, active 17.4–20.5 hours, no side effects at lower doses), is novel neurogenic compound independent of monoamine reuptake pathways with phase 2 study showing 40mg dose resulted in significantly greater symptom reduction in major depressive disorder, undergoes hepatic metabolism via oxidation and conjugation with primary clearance through renal and biliary excretion, has been studied for treating PTSD, Alzheimer’s disease and age-related cognitive problems, reputation as emotional enhancer/increaser with tendency to skew towards childlike mindset, and is a selective glucocorticoid receptor agonist, making it valuable for investigators studying neurogenesis stimulation, antidepressant research, major depressive disorder, neurotrophic pathway modulation, hippocampal volume enhancement, PTSD, Alzheimer’s disease, age-related cognitive problems, and neurogenic small molecule pharmacology in in vitro and in vivo experimental models.

Handling & Storage Guidelines

• Long-Term Storage: Store in cool dry place, tightly sealed, away from heat, light and moisture; glass bottle provides UV protection; solution requires cool dry place storage; solutions can be stored at -20°C for up to 1 month

• Solubility: Supplied pre-dissolved in deionized water Type II at 40mg/mL; soluble in DMSO at 73 mg/mL (199.18 mM); soluble in Ethanol at 73 mg/mL (199.18 mM); insoluble in water; liquid appearance

• Pipette Measurement: Graduated pipette included for convenient measurement; less than 10% variance guarantees consistency

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. Always consult with a healthcare professional before starting any new supplement or research product. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.