Memantine HCl – Powder, 5g

Memantine HCl – Powder, 5g

This premium laboratory-grade research compound is supplied as ultra-pure raw lyophilized powder with white crystalline appearance, engineered for modern scientific investigations requiring precise NMDA receptor pharmacology and neuroprotection research. Memantine (1-amino-3,5-dimethyladamantane hydrochloride) is an adamantane derivative that acts as an uncompetitive, low-affinity, voltage-dependent, rapidly unbinding antagonist of NMDA glutamate receptors, functioning as an open-channel blocker that selectively enters the receptor-associated ion channel during its open state and blocks extrasynaptic NMDA receptors, preventing disruption of normal synaptic transmission and safeguarding against excitotoxicity-induced neuronal cell death, FDA-approved for moderate to severe dementia in Alzheimer’s disease and commonly used in combination with acetylcholinesterase inhibitors, demonstrating neuroprotective properties valuable for in vitro/in vivo modeling of Alzheimer’s disease, Parkinsonism, epilepsy, motor neurone disease, traumatic brain injury, and cognitive impairment research.

All domestic orders ship directly from primary United States production facilities, ensuring rapid delivery to all 50 U.S. states. International orders to the UK and continental Europe are fulfilled through our dedicated United Kingdom shipping hub, enabling seamless, efficient customs clearance across European borders without delay.

• Lot-coded containers with publicly accessible third-party HPLC/GC lab reports verifying specification ≥98% purity for absolute transparency

• Formulation completely free of adulterants, excipients, and flow agents to guarantee raw chemical purity

• Strategic over-weighing inside the vessel compensates for natural adhesion loss during laboratory transfer

• Packaging engineering utilizes a glass vial with tamper-proof seal to maintain chemical stability during transit and storage at +4°C

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

NMDA Receptor Antagonist with Neuroprotective Profile

Memantine HCl functions as an uncompetitive, low-affinity, voltage-dependent, rapidly unbinding antagonist of NMDA (N-methyl-D-aspartate) glutamate receptors that acts as an open-channel blocker selectively entering the receptor-associated ion channel during its open state and blocking extrasynaptic NMDA receptors (NMDAR), preventing disruption of normal synaptic transmission and safeguarding against excitotoxicity-induced neuronal cell death. Memantine is an adamantane derivative effective against Alzheimer’s disease and Parkinson’s disease, also useful in treating epilepsy, motor neurone disease and trauma, FDA-approved for moderate to severe dementia in Alzheimer’s disease and commonly used in combination with acetylcholinesterase inhibitors for Alzheimer dementia treatment. The antagonist activity of memantine (2-33 µM) on NMDA receptors of cultured superior collicular and hippocampal neurons has been studied extensively, with protective effect against NMDA receptor-mediated glutamate toxicity in cultured cerebellar, cortical and mesencephalic neurons investigated, demonstrating memantine (100 µM) diminishes spontaneous synaptic activity with action potential frequencies above 6 Hz in cultured mouse nerve cells, and memantine (2 µM) reduces neuronal damage caused by HIV-1 coat protein gp120 in cultured rat ganglion retinal cells. Memantine exerts action through uncompetitive NMDA receptor antagonism, binding preferentially to NMDA receptor-operated cation channels, and also has antagonistic activity at type 3 serotonergic (5-HT3) receptor with potency similar to NMDA receptor, and lower antagonistic activity at nicotinic acetylcholine receptor, stimulating dopamine release, making it valuable for investigators studying Alzheimer’s disease mechanisms, Parkinsonism, neuroprotection, excitotoxicity prevention, cognitive impairment, traumatic brain injury, epilepsy, motor neurone disease, and NMDA receptor pharmacology in in vitro and in vivo experimental models.

Handling & Storage Guidelines

• Long-Term Storage: Store at +4°C refrigerated in tightly sealed container, desiccated at room temperature for up to 1 year; stable ≥4 years under proper storage conditions

• Solubility: Water: 1 mg/mL; soluble in water (up to 20 mg/mL); standard aqueous solubility for hydrochloride salt form

• Appearance: White crystalline powder, solid form with melting point 292°C

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.