J147 – Powder, 500mg

J147 – Powder, 500mg

This premium laboratory-grade research compound is supplied as ultra-pure raw lyophilized powder with yellow to off-white crystalline appearance, engineered for modern scientific investigations requiring precise neurotrophic and neuroprotective pharmacology. J147 is a potent, orally active broadly neuroprotective phenyl hydrazide compound designed as an analogue of curcumin (curry spice component) with better stability and bioavailability that induces brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), enhances long-term potentiation (LTP), preserves synaptic proteins, reduces amyloid plaques, reverses cognitive impairment in aged Alzheimer’s disease mice even when administered at late disease stage, prevents memory deficits in AD transgenic mice, enhances memory in normal animals, and demonstrates therapeutic potential for Alzheimer’s disease, diabetic neuropathy, ischemic stroke, traumatic brain injury, depression, anxiety, and fatty liver disease, making it a valuable tool for in vitro/in vivo modeling of neurodegenerative diseases, cognitive impairment research, and memory enhancement studies.

All domestic orders ship directly from primary United States production facilities, ensuring rapid delivery to all 50 U.S. states. International orders to the UK and continental Europe are fulfilled through our dedicated United Kingdom shipping hub, enabling seamless, efficient customs clearance across European borders without delay.

• Lot-coded containers with publicly accessible third-party HPLC/LC-MS lab reports verifying specification >98% purity for absolute transparency

• Formulation completely free of adulterants, excipients, and flow agents to guarantee raw chemical purity

• Strategic over-weighing inside the vessel compensates for natural adhesion loss during laboratory transfer

• Packaging engineering utilizes a glass vial with tamper-proof seal to maintain chemical stability during transit and room temperature storage

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

Neurotrophic/Neuroprotective Compound with BDNF Induction and AMPK Activation Profile

J147 functions as a potent, orally active broadly neuroprotective phenyl hydrazide compound designed as an analogue of curcumin with better stability and bioavailability that induces brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), enhances long-term potentiation (LTP), preserves synaptic proteins, and reduces amyloid plaques. The neurotrophic and memory-enhancing activities of J147 are associated with increased BDNF levels and expression of BDNF-responsive proteins important for learning and memory, with neurotrophic/BDNF-like activities independent of the BDNF receptor TrkB. J147 protects against neurotoxicity in cortical neurons in vitro with EC50=60-115 nM (broad spectrum neuroprotective phenyl hydrazide), reverses cognitive impairment in aged Alzheimer’s disease mice when administered at late disease stage, preventing memory deficits in AD transgenic mice, and enhancing memory in normal animals, demonstrating immediate cognition benefits and potential to halt and perhaps reverse disease progression in symptomatic animals. The neuroprotective effect of J147 is partially achieved by binding to and inhibiting the alpha subunit of mitochondrial ATP synthase while simultaneously activating AMP-activated protein kinase (AMPK), and J147 treatment protects against traumatic brain injury by inhibiting neuronal endoplasmic reticulum (ER) stress via the AMPK/SREBP-1 pathway, with multiple behavioral assessments over 35 days revealing significant dose-dependent improvement in neurofunctional recovery, reduced acute neurodegeneration, enhanced long-term neuron survival, and improved neuroplasticity. J147 has neurotrophic and BDNF-like activities, appears to have a small but significant effect on Aβ metabolism by reducing Aβ1-42 in the soluble fraction of the hippocampus, and demonstrates accumulating evidence for potential role in prevention and treatment of Alzheimer’s disease, diabetic neuropathy, ischemic stroke, depression, anxiety, and fatty liver disease, suggesting it as a potential target for prevention and treatment of neurological diseases. J147 is extremely potent, safe in animal studies, and orally active, making it valuable for investigators studying neurodegenerative diseases, cognitive impairment, traumatic brain injury, memory enhancement, BDNF/NGF induction, mitochondrial dysfunction, ER stress pathways, AMPK activation, amyloid metabolism, and neuroprotection mechanisms in in vitro and in vivo experimental models.

Handling & Storage Guidelines

• Long-Term Storage: Store at room temperature in tightly sealed container, away from heat, light and moisture; some suppliers recommend refrigerator storage; stable under normal storage conditions

• Solubility: DMSO: 25 mg/mL (71.36 mM); DMSO soluble to 50 mg/mL; standard organic solvent compatibility for phenyl hydrazide derivative

• Appearance: Yellow to off-white crystalline powder, solid form

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.