N-Acetyl-Semax – Spray

$74.99

  • N-Acetyl-Semax – Spray is a high-purity laboratory-grade research peptide supplied as a ready-to-use aqueous solution (concentration varies by variant: 1mg/mL, 2mg/mL ± 10% in deionized water Type II), functioning as an advanced acetylated derivative of Semax—a synthetic heptapeptide analog of the N-terminal domain of adrenocorticotropic hormone (ACTH) encompassing Met-Glu-His-Phe-Pro-Gly-Pro sequence with cognitive-enhancing, neuroprotective, BDNF upregulating, and dopamine-modulating properties that exhibits enhanced metabolic stability, prolonged activity, and improved blood-brain barrier penetration compared to parent Semax, modulates brain-derived neurotrophic factor (BDNF) expression affecting neuroplasticity and cognitive function, and affects dopamine neurotransmitter levels, supplied with BKC (benzyl chloride potassium) stabilizer for solution stability, available in amber glass nasal spray bottle with graduated spray mechanism for convenient measurement, available for fast, compliant shipping to all U.S. states and European countries.

    • ≥99% peptide-grade purity verified by LC-MS with public lot-coded certificates of analysis for absolute transparency

    • Formulation contains N-Acetyl-Semax peptide in deionized water Type II with stabilizer for solution stability

    • Amber glass spray bottle with UV resistance and graduated nasal spray mechanism engineered for convenient laboratory measurement and storage at 4°C

    • Less than 10% variance in concentration, guaranteeing consistency and measurement accuracy

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Description

N-Acetyl-Semax – Spray

This premium laboratory-grade research peptide is supplied as a ready-to-use aqueous solution engineered for modern scientific investigations requiring precise neuropeptide pharmacology and cognitive/neuroprotection research. N-Acetyl-Semax (Acetyl Semax) is an advanced, N-terminal acetylated derivative of Semax—a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) that encompasses the sequence 4-7 of N-terminal domain of the adrenocorticotropic hormone (ACTH), functioning as a nootropic and neuroprotective peptide with cognitive-enhancing properties improving concentration, memory, and learning, stress resilience support, neuroplasticity enhancement, BDNF upregulation affecting neuroplasticity and cognitive function, dopamine modulation affecting neurotransmitter levels, and enhanced metabolic stability with prolonged activity and improved blood-brain barrier penetration compared to parent Semax, making it a valuable tool for in vitro/in vivo modeling of cognitive enhancement, neuroprotection, neurodegenerative diseases, stress resilience, BDNF-mediated neuroplasticity, and dopamine pathway modulation research.

All domestic orders ship directly from primary United States production facilities, ensuring rapid delivery to all 50 U.S. states. International orders to the UK and continental Europe are fulfilled through our dedicated United Kingdom shipping hub, enabling seamless, efficient customs clearance across European borders without delay.

  • Lot-coded containers with publicly accessible third-party LC-MS/MS lab reports verifying specification ≥99% peptide-grade purity for absolute transparency

  • Formulation contains N-Acetyl-Semax peptide in deionized water Type II with stabilizer to guarantee solution stability and peptide integrity

  • Amber glass nasal spray bottle with UV resistance and graduated spray mechanism maintains peptide stability during transit and refrigerated storage at 4°C

  • Multiple concentration variants available with less than 10% variance guaranteeing consistency


Technical Specifications & Chemical Profile

Chemical Property Specification Data
Product Name N-Acetyl-Semax – Spray
Common Synonyms Acetyl Semax, N-Acetyl Semax, Ac-Semax, N-Acetyl Semax Amidate, Met-Glu-His-Phe-Pro-Gly-Pro, ACTH fragment analog, ACTH (4-10), melanocortin peptide, heptapeptide, neuropeptide, nootropic peptide, neuroprotective peptide, cognitive enhancer peptide
CAS Number 80714-61-0 (parent Semax); 2920938-90-3 (N-Acetyl Semax Amidate)
Molecular Formula C₃₇H₅₁N₉O₁₀S (N-Acetyl Semax Amidate)
Molar Mass 853.95 g/mol (N-acetylated); 858.97 g/mol (Amidate form)
Amino Acid Sequence Met-Glu-His-Phe-Pro-Gly-Pro (N-acetylated at N-terminus)
Primary Target Mechanism Advanced N-terminal acetylated derivative of Semax; synthetic analog of ACTH N-terminal domain fragment (ACTH 4-10); heptapeptide encompassing sequence 4-7 of ACTH N-terminal domain; N-terminal acetylation modulates chemical and biological properties of parental peptide; cognitive enhancer improving concentration, memory, and learning ability; neuroprotective effects protecting neurons from damage/degeneration; nootropic peptide; BDNF upregulation affecting neuroplasticity and cognitive function; dopamine modulation (augmenting psychostimulant effects on central dopamine release) affecting neurotransmitter levels; stress resilience support; neuroplasticity enhancement; enhanced metabolic stability; prolonged activity; improved blood-brain barrier penetration; stimulates memory and attention after intranasal application; improves selective attention; modulates brain development; potential therapeutic agent for ADHD and Rett syndrome; non-sedating and non-addictive; no tolerance or withdrawal; bitter taste; used as prescription drug in Russia for stroke, transient ischemic attack, memory and cognitive disorders, peptic ulcers, optic nerve disease, and immune system boosting; poor oral bioavailability; administered as nasal spray or subcutaneous injection
Physical Form Liquid, solved in Deionized Water (Type II); clear, colorless liquid
Purity ≥99% Pure (Validated by LC-MS)
Concentration Variants Multiple variants available: 15mL liquid solution (concentration varies)
Storage Condition Store cold, keep refrigerated (4°C); Do NOT freeze

Research Applications & Storage Protocols

N-Acetylated Semax Analog with BDNF Upregulation and Dopamine Modulation Profile

N-Acetyl-Semax functions as an advanced, N-terminal acetylated derivative of Semax—a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) that encompasses the sequence 4-7 of N-terminal domain of adrenocorticotropic hormone (ACTH), with N-terminal acetylation modulating the chemical and biological properties of parental peptide. The peptide demonstrates cognitive-enhancing properties improving concentration, memory, and learning ability, exhibits neuroprotective effects protecting neurons from damage or degeneration, serves as nootropic peptide, upregulates brain-derived neurotrophic factor (BDNF) affecting neuroplasticity and cognitive function (stimulates central BDNF synthesis), modulates dopamine (augments effects of psychostimulants on central dopamine release) affecting neurotransmitter levels, provides stress resilience support, enhances neuroplasticity, demonstrates enhanced metabolic stability with prolonged activity and improved blood-brain barrier penetration compared to parent Semax, stimulates memory and attention in rodents and humans after intranasal application, improves selective attention and modulates brain development, with potential therapeutic potential for ADHD and Rett syndrome by increasing central BDNF activity, making it valuable for investigators studying cognitive enhancement, neuroprotection, neurodegenerative diseases, stress resilience, memory and learning mechanisms, BDNF-mediated neuroplasticity, dopamine pathway modulation, attention and focus improvement, mental performance under stress, and neuropeptide pharmacology in in vitro and in vivo experimental models. Semax (parent peptide) is a medication used in Eastern Europe particularly Russia for treatment of broad range of conditions like brain trauma but predominantly for claimed nootropic, neuroprotective, and neurorestorative effects, is synthetic analogue of ACTH fragment ACTH (4-10), has poor oral bioavailability and is administered parenterally as nasal spray or subcutaneous injection, stimulates memory and attention after intranasal application, and is on Russian List of Vital & Essential Drugs, providing reference point for N-Acetyl-Semax research applications.

Handling & Storage Guidelines

  • Long-Term Storage: Store in refrigerator at 4°C, keep refrigerated, tightly sealed, away from heat, light and moisture; amber glass bottle provides UV protection; peptide solution requires refrigeration to remain stable; Do NOT freeze

  • Solubility: Supplied pre-dissolved in deionized water Type II; soluble in water; clear, colorless liquid appearance

  • Spray Mechanism: Amber glass nasal spray bottle included; graduated spray mechanism for convenient measurement; 15mL total volume

  • Administration (Research): Intranasal (preferred via nasal spray), or subcutaneous injection; poor oral bioavailability

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering. N-Acetyl Semax is not approved by the FDA and is sold strictly for scientific research use only. It is not intended for human or veterinary use.

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