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NSI-189 Free Base 1200mg (40mg/mL) bioactive solution in UV-resistant glass bottle with graduated pipette for US and European laboratory neurogenesis, antidepressant, and cognitive enhancement studies
N-Acetyl-Semax-Amidate – Spray Price range: $49.99 through $112.49

N-Acetyl-Semax-Amidate – Aliquot, 50mg

$79.99

  • N-Acetyl-Semax-Amidate – Aliquot, 50mg is a high-purity laboratory-grade research peptide in lyophilized (freeze-dried) powder form, functioning as an advanced acetylated and amidated derivative of Semax—a synthetic heptapeptide analog of the ACTH(4-10) fragment (Met-Glu-His-Phe-Pro-Gly-Pro) with cognitive-enhancing, neuroprotective, BDNF upregulating, and dopamine-modulating properties that exhibits significantly increased duration, potency, metabolic stability, enhanced receptor affinity, extended half-life, and improved blood-brain barrier penetration compared to parent Semax, modulates brain-derived neurotrophic factor (BDNF) levels affecting neuroplasticity and cognitive function, modulates dopamine and serotonin transmission affecting neurotransmitter levels, and reduces inflammation in brain tissue, available for fast, compliant shipping to all U.S. states and European countries.

    • ≥99% peptide-grade purity verified by HPLC with public lot-coded certificates of analysis for absolute transparency

    • Formulation completely free of adulterants, excipients, and flow agents – 100% raw peptide ingredient

    • Lyophilized peptide grade with ≥99% purity validated by analytical HPLC and mass spectrometry

    • Glass vial with tamper-proof seal engineered for safe international transit and cold storage at -20°C

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Description

N-Acetyl-Semax-Amidate – Aliquot, 50mg

This premium laboratory-grade research peptide is supplied as ultra-pure lyophilized (freeze-dried) powder engineered for modern scientific investigations requiring precise neuropeptide pharmacology and cognitive/neuroprotection research. N-Acetyl-Semax-Amidate is an advanced, N-acetylated and C-terminally amidated derivative of Semax—a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) that encompasses the ACTH(4-10) fragment, functioning as a nootropic and neuroprotective peptide with cognitive-enhancing properties improving concentration, working memory, mental stamina, and learning speed, stress resilience support, neuroplasticity enhancement without causing jitteriness, BDNF upregulation affecting neuroplasticity and cognitive function (increases central BDNF synthesis), dopamine and serotonin modulation affecting neurotransmitter levels (increases dopaminergic signaling supporting concentration and motivation), anti-inflammatory effects reducing inflammation in brain tissue, and significantly increased duration, potency, and metabolic stability with enhanced receptor affinity, extended half-life, and improved blood-brain barrier penetration compared to parent Semax, making it a valuable tool for in vitro/in vivo modeling of cognitive enhancement, neuroprotection, neurodegenerative diseases, stress resilience, burnout/brain fog, BDNF-mediated neuroplasticity, dopamine/serotonin pathway modulation, and anti-inflammatory brain research.

All domestic orders ship directly from primary United States production facilities, ensuring rapid delivery to all 50 U.S. states. International orders to the UK and continental Europe are fulfilled through our dedicated United Kingdom shipping hub, enabling seamless, efficient customs clearance across European borders without delay.

  • Lot-coded containers with publicly accessible third-party HPLC lab reports verifying specification ≥99% peptide-grade purity for absolute transparency

  • Formulation completely free of adulterants, excipients, and flow agents to guarantee raw peptide purity

  • Strategic lyophilization stabilizes peptide structure for long-term storage and maintains integrity during transit

  • Packaging engineering utilizes a glass vial with tamper-proof seal to maintain peptide stability during transit and cold storage at -20°C


Technical Specifications & Chemical Profile

Chemical Property Specification Data
Product Name N-Acetyl-Semax-Amidate – Aliquot, 50mg
Common Synonyms N-Acetyl Semax Amidate, Ac-Semax-Amidate, Met-Glu-His-Phe-Pro-Gly-Pro-NH2, ACTH(4-10) analog, ACTH fragment analog, N-acetyl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-prolyl-glycyl-L-prolinamide, heptapeptide, neuropeptide, nootropic peptide, neuroprotective peptide, cognitive enhancer peptide
CAS Number 2920938-90-3
Molecular Formula C₃₉H₅₄N₁₀O₁₀S
Molar Mass 855.0 g/mol
Amino Acid Sequence Met-Glu-His-Phe-Pro-Gly-Pro (N-acetylated at N-terminus, C-terminal amidation)
Modifications N-Acetylation at N-terminus for metabolic stability; C-terminal amidation for enhanced receptor affinity and half-life
Primary Target Mechanism Advanced N-acetylated and C-terminally amidated derivative of Semax; synthetic analog of ACTH(4-10) fragment; heptapeptide; N-acetylation at N-terminus for metabolic stability; C-terminal amidation for enhanced receptor affinity and half-life; cognitive enhancer improving concentration, working memory, mental stamina, and learning speed without causing jitteriness; neuroprotective effects protecting neurons from damage/degeneration; nootropic peptide; BDNF upregulation (increases central BDNF synthesis) affecting neuroplasticity and cognitive function; dopamine and serotonin modulation (increases dopaminergic signaling supporting concentration and motivation) affecting neurotransmitter levels; stress resilience support, especially under stress; neuroplasticity enhancement; enhanced metabolic stability; significantly increased duration and potency; enhanced receptor affinity; extended half-life; improved blood-brain barrier penetration; anti-inflammatory effects reducing inflammation in brain tissue; helps recalibrate cognitive function from inside out without overstimulation of caffeine or prescription stimulants; non-sedating and non-addictive; no tolerance or withdrawal; used for research in neuroprotection and cognitive function; used for research of biochemical studies, neurogenic, neuroregulatory, and neurorestorative biological processes
Physical Form Lyophilized (freeze-dried) powder; white to off-white solid; only lyophilized product provided
Purity ≥98% Peptide-Grade (Validated by HPLC); ≥99% Pure
Availability Multiple quantities available: 10mg, 15mg, 20mg, 50mg, 100mg lyophilized powder (requires reconstitution)

Research Applications & Storage Protocols

N-Acetylated and Amidated Semax Analog with BDNF Upregulation and Dopamine Modulation Profile

N-Acetyl-Semax-Amidate functions as an advanced, N-acetylated and C-terminally amidated derivative of Semax—a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) that encompasses the ACTH(4-10) fragment, with N-acetylation at N-terminus for metabolic stability and C-terminal amidation for enhanced receptor affinity and half-life. The peptide demonstrates cognitive-enhancing properties improving concentration, working memory, mental stamina, and learning speed without causing jitteriness, exhibits neuroprotective effects protecting neurons from damage or degeneration, serves as nootropic peptide, upregulates brain-derived neurotrophic factor (BDNF) increasing central BDNF synthesis affecting neuroplasticity and cognitive function, modulates dopamine and serotonin (increases dopaminergic signaling supporting concentration and motivation) affecting neurotransmitter levels, provides stress resilience support especially under stress, enhances neuroplasticity, demonstrates enhanced metabolic stability with significantly increased duration, potency, enhanced receptor affinity, extended half-life, and improved blood-brain barrier penetration compared to parent Semax, reduces inflammation in brain tissue, helps recalibrate cognitive function from inside out without overstimulation of caffeine or prescription stimulants, making it valuable for investigators studying cognitive enhancement, neuroprotection, neurodegenerative diseases, stress resilience, burnout/brain fog, memory and working memory mechanisms, BDNF-mediated neuroplasticity, dopamine/serotonin pathway modulation, anti-inflammatory brain research, attention and focus improvement, learning speed, mental performance, and neuropeptide pharmacology in in vitro and in vivo experimental models. Semax (parent peptide) is a short-chain peptide obtained by chemical synthesis methods constructed from seven amino acids, synthetic analogue of ACTH fragment, used as medication in Eastern Europe particularly Russia for broad range of conditions providing reference point for N-Acetyl-Semax-Amidate research applications.

Handling & Storage Guidelines

  • Long-Term Storage: Store lyophilized peptide at -20°C for long-term preservation; following reconstitution in sterile water, aliquot and freeze at -80°C; stock solutions stable for up to 1 year at -80°C; lyophilized peptides require refrigeration to remain stable; avoid repeated freeze–thaw cycles

  • Solubility: Reconstitute in sterile water, bacteriostatic water, or appropriate aqueous buffer; requires reconstitution; standard peptide solubility; lyophilized form for stability; only lyophilized product provided

  • Appearance: White to off-white lyophilized (freeze-dried) powder, solid form

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is supplied exclusively to qualified professionals for in-vitro research. Supplied as lyophilized powder requiring reconstitution. For laboratory use only—no human or veterinary applications. This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. Always consult with a healthcare professional before starting any new supplement or research product. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.

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