GSK2881078 – Solution, 300mg (10mg/mL)

GSK2881078 – Solution, 300mg (10mg/mL)

This premium, laboratory-grade research compound delivers ultra-pure GSK2881078 solution at 10mg/mL concentration, representing the highest standard for modern scientific investigations into selective androgen receptor modulation and anabolic signaling mechanisms in muscle and bone. The ready-to-use solution format eliminates preparation time and ensures precise dosing accuracy for in vivo animal studies, eliminating solubility variability and providing investigators with a validated vehicle system ideal for analytical testing, pharmacokinetic modeling, and in vivo preclinical research applications where precise GSK2881078 administration is critical for studying tissue-selective androgenic effects with greater tissue selectivity than testosterone-based approaches.

All shipments to the 50 United States are fulfilled directly from primary U.S. production facilities, ensuring 2-5 business day delivery nationwide. International orders to the United Kingdom and continental Europe are processed through our dedicated United Kingdom shipping hub, which streamlines customs clearance and reduces transit times across all European countries. This dual-hub logistics infrastructure guarantees seamless, compliant delivery while maintaining chemical integrity throughout transit.

• Public third-party lab reports with unique lot-coding ensure absolute transparency for every batch sold

• Formulation contains zero adulterants, excipients, flow agents, or contaminants—pure GSK2881078 solution only

• Strategic over-fill compensates for solution adhesion loss, guaranteeing minimum 30mL (300mg) recoverable volume

• Amber glass bottle features UV-resistant construction and tamper-proof seal for transit safety

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

SARM-Mediated AR Agonism & Lean Mass Enhancement Profiling

GSK2881078 (GSK-2881078, GSK’078) functions as an orally bioavailable, small molecule, nonsteroidal selective androgen receptor modulator (SARM) developed by GlaxoSmithKline (GSK) to treat age-related muscle atrophy (loss of skeletal muscle mass, quality, and strength). The compound is a potent and selective androgen receptor modulator that acts as a partial androgen receptor (AR) agonist in androgenic tissues, being evaluated for effects on muscle growth and strength in subjects with muscle wasting and potentially for treatment of cachexia. GSK2881078 has been examined for its ability to stimulate anabolic signaling in muscle and bone while aiming to lessen the broad androgenic effects typical of conventional androgens, making it a tool to isolate androgen receptor-driven effects with greater tissue selectivity than testosterone-based approaches. In Phase 1b clinical studies, GSK2881078 produced anabolic effects (increased lean mass) and was well tolerated, yielding dose-dependent increases in lean mass with evidence of enhanced sensitivity in women. The compound was advanced to Phase 2 clinical evaluation in patients with cachexia related to chronic obstructive pulmonary disease (COPD), and compared with placebo, there was greater lean mass accrual with all dose levels of GSK2881078, which was generally well tolerated with no serious adverse events reported. However, in mid-2020, GSK made the decision to terminate this development programme as their trial data did not support progression for COPD, making GSK2881078 primarily a research tool compound rather than a therapeutic candidate. In research settings, it is mainly used in studies of lean-mass preservation, functional performance, and catabolic conditions where androgen receptor activity is a key factor. This SARM mechanism positions GSK2881078 solution as a critical tool compound for investigating muscle growth research, lean mass preservation models, age-related muscle atrophy (sarcopenia) studies, functional performance enhancement, cachexia treatment pathways, muscle wasting conditions, and tissue-selective androgen receptor signaling in preclinical models, offering potential therapeutic insights for metabolic and endocrine disorders.

Handling & Storage Guidelines

• Long-Term Storage: Store at room temperature (15-25°C) in a cool, dry place away from direct sunlight to maintain potency and maximize shelf life (up to 2 years). UV-resistant glass bottle minimizes degradation; tamper-proof seal ensures secure delivery. Avoid excessive heat and moisture

• Solubility: Pre-dissolved formulation ready for direct use; DMSO: 60-66 mg/mL (181-199 mM), sonication recommended; Ethanol: 50 mg/mL; Water: <1 mg/mL (insoluble); DMF: 25 mg/mL; shake/agitate bottle before each administration for consistency

• Appearance: Clear colorless to pale yellow liquid solution; 30mL volume containing 300mg total GSK2881078 at 10mg/mL concentration; <5% concentration variance for consistency

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.