ISRIB – Powder, 500mg

ISRIB – Powder, 500mg

This premium laboratory-grade research compound is supplied as ultra-pure raw lyophilized powder with white crystalline appearance, engineered for modern scientific investigations requiring precise integrated stress response (ISR) inhibition and eIF2B modulation. ISRIB (short for “integrated stress response inhibitor”) is a blood-brain barrier penetrant, potent and selective inhibitor that acts as a molecular staple pinning together tetrameric subcomplexes of eIF2B along the assembly path to a fully active decameric enzyme, thereby blocking ISR and restoring the cell’s translation capacity, showing promising results in mouse models of brain disorders including traumatic brain injury, Fragile X syndrome, Alzheimer’s disease, and Parkinson’s disease, making it a valuable tool for in vitro/in vivo modeling of neurodegenerative diseases, cognitive impairment research, and memory enhancement studies.

All domestic orders ship directly from primary United States production facilities, ensuring rapid delivery to all 50 U.S. states. International orders to the UK and continental Europe are fulfilled through our dedicated United Kingdom shipping hub, enabling seamless, efficient customs clearance across European borders without delay.

• Lot-coded containers with publicly accessible third-party HPLC/LC-MS lab reports verifying specification ≥98% purity for absolute transparency

• Formulation completely free of adulterants, excipients, and flow agents to guarantee raw chemical purity

• Strategic over-weighing inside the vessel compensates for natural adhesion loss during laboratory transfer

• Packaging engineering utilizes a glass vial with tamper-proof seal to maintain chemical stability during transit and cold storage at -20°C

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

Integrated Stress Response (ISR) Inhibitor with eIF2B Activation Profile

ISRIB functions as a potent and selective blood-brain barrier penetrant inhibitor of the integrated stress response (ISR) that allosterically antagonizes the inhibitory effect of phosphorylated eIF2 on eIF2B, binding to the active structure of translation initiation factor eIF2B to prevent structural changes of eIF2B due to phosphorylated eIF2 (the inhibitor of eIF2B produced in stress environment) into an inhibitory form, thereby suppressing the progression of the ISR pathway and restoring cellular translation capacity. To determine ISRIB’s mechanism of action, researchers solved an atomic structure of ISRIB bound to the human eIF2B decamer, finding that ISRIB acts as a molecular staple pinning together tetrameric subcomplexes of eIF2B along the assembly path to a fully active, decameric enzyme. ISRIB potently reverses the effects of eIF2α phosphorylation with IC50=5 nM, enhances spatial and fear-associated learning in mice and enhances cognitive function, suppresses ER stress-induced inflammatory gene expression, and potently attenuates amyloid β-induced neuronal cell death (12.5–25 nM) with no effect on amyloid β production. ISRIB completely eliminates learning and memory deficits in mice with concussions and reverses neuronal and cognitive effects of traumatic brain injury (TBI) weeks after injury occurred, with mice treated with the drug showing sustained improvements in working memory. ISR activation has been implicated in many neurological disorders including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), making ISRIB valuable for investigators studying neurodegenerative diseases, cognitive impairment, traumatic brain injury, Fragile X syndrome, memory enhancement, and cellular stress response pathways in in vitro and in vivo experimental models. Early-stage human trials are already underway to test ISRIB for safety and effectiveness in treating brain injuries and neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

Handling & Storage Guidelines

• Long-Term Storage: Store powder at -20°C for up to 3 years; following reconstitution, aliquot and freeze at -80°C; stock solutions stable for up to 1 year at -80°C; some suppliers recommend -20°C storage

• Solubility: DMSO: 50 mg/mL (110.78 mM); DMSO soluble to 100 mg/mL; standard organic solvent compatibility for thiazolidine derivative

• Appearance: White crystalline powder, solid form

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.