NSI-189 Phosphate – Powder, 1g

Main Description

NSI-189 Phosphate – Powder, 1g

This premium laboratory-grade research neurogenic compound is supplied as ultra-pure white crystalline powder engineered for modern scientific investigations requiring precise neurogenic small molecule pharmacology and neurogenesis/antidepressant research. NSI-189 Phosphate is the phosphate salt form of NSI-189 (NeuralStem Inc-189, Amdiglurax, ALTO-100, NSI-189 Free Base), a benzylpiperizine-aminiopyridine novel chemical entity developed by Neuralstem for treatment of cognitive disorders and major depressive disorder, with neurogenesis stimulation, antidepressant (non-monoamine based), procognitive, synaptoplastic, and neurotrophic effects that promotes proliferation and differentiation of neural stem/progenitor cells, stimulates neurogenesis of human hippocampus-derived neural stem cells in vitro and stimulates neurogenesis in murine hippocampus in vivo with regionally specific effects observed largely in subventricular zone of hippocampus, increases hippocampal volume, exhibits antidepressant effects mitigating depressive symptoms and improving cognitive function in adults with DSM-5-defined Major Depressive Disorder (MDD), is a novel multi-domain neurogenic compound with brain-therapeutic properties with potential therapeutic applications across disparate psychiatric disorders including depression, bipolar depression, and cognition, has half-life of approximately 20 hours with typical dose 40-120 mg/day (optimal 40mg once or twice daily for 28 days, no significant improvement at 120mg/day), was studied in phase 1b placebo-controlled double-blind trial in 24 MDD patients for 28 days using 40mg/80mg/120mg per day showing over-round positive changes during drug taken period and in follow up days with no side effects at lower doses but no significant improvement at 120mg/day, and phase 2 study evaluating oral NSI-189 phosphate as monotherapy in major depressive disorder, making it a valuable tool for in vitro/in vivo modeling of neurogenesis stimulation, antidepressant research, major depressive disorder, multi-domain psychiatric disorders, neurotrophic pathway modulation, hippocampal volume enhancement, cognition improvement, procognitive effects, synaptoplastic effects, and neurogenic small molecule pharmacology research.

All domestic orders ship directly from primary United States production facilities, ensuring rapid delivery to all 50 U.S. states. International orders to the UK and continental Europe are fulfilled through our dedicated United Kingdom shipping hub, enabling seamless, efficient customs clearance across European borders without delay.

• Batch-coded containers with publicly accessible lab reports verifying specification 99.95% purity for absolute transparency (may vary between batches)

• Formulation completely free of adulterants, excipients, and flow agents to guarantee raw chemical purity

• Strategic crystallization stabilizes compound structure for long-term storage and maintains integrity during transit

• Packaging engineering utilizes a glass jar with tamper-proof seal to maintain powder stability during transit and cool dry place storage minimizing contact with open air

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

Multi-Domain Neurogenic Compound with Hippocampal Neurogenesis and Antidepressant Profile

NSI-189 Phosphate functions as the phosphate salt of NSI-189, a benzylpiperizine-aminiopyridine novel chemical entity developed by Neuralstem for treatment of cognitive disorders and major depressive disorder, that stimulates neurogenesis of human hippocampus-derived neural stem cells in vitro and stimulates neurogenesis in murine hippocampus in vivo with regionally specific effects observed largely in subventricular zone of hippocampus. The compound demonstrates neurogenic small molecule that promotes proliferation and differentiation of neural stem/progenitor cells, increases hippocampal volume, exhibits antidepressant effects (non-monoamine based) mitigating depressive symptoms and improving cognitive function in adults with DSM-5-defined Major Depressive Disorder (MDD), is novel multi-domain neurogenic compound with brain-therapeutic properties with potential therapeutic applications across disparate psychiatric disorders including depression, bipolar depression, and cognition, has procognitive effects, synaptoplastic effects, and neurotrophic effects, was studied in phase 1b placebo-controlled double-blind trial in 24 MDD patients for 28 days using 40mg/80mg/120mg per day (40mg one time dose, frequency varies: once daily, twice daily, three times daily) showing over-round positive changes during drug taken period and in follow up days with no side effects at lower doses but no significant improvement at 120mg/day, has half-life of approximately 20 hours with typical dose 40-120 mg/day and optimal 40mg once or twice daily for 28 days, and is undergoing phase 2 study evaluating oral NSI-189 phosphate as monotherapy in major depressive disorder (40mg once daily), making it valuable for investigators studying neurogenesis stimulation, antidepressant research, major depressive disorder, multi-domain psychiatric disorders, neurotrophic pathway modulation, hippocampal volume enhancement, cognition improvement, procognitive effects, synaptoplastic effects, and neurogenic small molecule pharmacology in in vitro and in vivo experimental models.

Handling & Storage Guidelines

• Long-Term Storage: Store in cool dry place, tightly sealed, away from heat, light and moisture; minimize contact with open air; crystalline powder stable in cool dry place; store container tightly closed in dry, cool place

• Solubility: Soluble in DMSO; white crystalline powder appearance

• Appearance: White crystalline powder, solid form

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. Always consult with a healthcare professional before starting any new supplement or research product. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.