Cardarine (GW501516) – Powder, 1g

Cardarine (GW501516) – Powder, 1g

This premium, laboratory-grade research compound delivers ultra-pure raw Cardarine powder at ≥98% purity, representing the highest standard for modern scientific investigations into PPARδ receptor activation and metabolic regulation mechanisms. The lyophilized crystalline powder form provides investigators with a single-compound reference standard ideal for analytical testing, in vitro cell culture modeling of metabolic pathways, and in vivo preclinical research applications where precise GW501516 isolation is critical for studying lipid metabolism enhancement, fatty acid oxidation, and exercise-mimetic pathways.

All shipments to the 50 United States are fulfilled directly from primary U.S. production facilities, ensuring 2-5 business day delivery nationwide. International orders to the United Kingdom and continental Europe are processed through our dedicated United Kingdom shipping hub, which streamlines customs clearance and reduces transit times across all European countries. This dual-hub logistics infrastructure guarantees seamless, compliant delivery while maintaining chemical integrity throughout transit.

• Public third-party lab reports with unique lot-coding ensure absolute transparency for every batch sold

• Formulation contains zero adulterants, excipients, flow agents, or contaminants—pure Cardarine only

• Strategic over-weighing compensates for powder adhesion loss, guaranteeing minimum 1g recoverable material

• PET single-wall jar features UV-resistant construction and tamper-proof seal for transit safety

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

PPARδ Agonism & Lipid Metabolism Enhancement Profiling

Cardarine (GW501516, GW-501516) functions as a potent and highly selective peroxisome proliferator-activated receptor delta (PPARβ/δ) agonist with an EC₅₀ of 1 nM for PPARδ and greater than 1000-fold selectivity over PPARα and PPARγ subtypes. The compound dramatically activates fatty acid beta-oxidation pathways, increases mitochondrial biogenesis in skeletal muscle and cardiac tissue, and enhances endurance capacity by activating some of the same pathways activated through exercise, making it an exercise mimetic agent. GW501516 dramatically increases serum high-density lipoprotein (HDL) cholesterol while lowering levels of small-dense low-density lipoprotein (LDL), fasting triglycerides, and free fatty acids, demonstrating profound effects on lipid metabolism and cardiovascular risk factors. Investigated as a potential treatment for obesity, diabetes, dyslipidemia, and cardiovascular disease due to its profound metabolic effects, GW501516 was developed through a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s. The compound has been demonstrated to increase HDL cholesterol by up to 50% and reduce LDL cholesterol by up to 25% in preclinical studies, while also improving insulin sensitivity and glucose metabolism. However, GW501516 showed increased cancer incidence in rats during long-term toxicity studies, leading to discontinuation of human clinical development, making it primarily a research tool compound rather than a therapeutic candidate. This PPARδ agonist mechanism positions Cardarine as a critical tool compound for investigating lipid metabolism research, dyslipidemia models, obesity studies, diabetes mechanisms, cardiovascular disease pathways, and exercise-mimetic metabolic regulation in preclinical models, offering potential therapeutic insights for metabolic disorders.

Handling & Storage Guidelines

• Long-Term Storage: Store at -20°C for optimal stability (up to 3 years); stable at room temperature for short-term storage. Minimize open air exposure; store in a cool, dry place in airtight conditions; protect from light and moisture

• Solubility: DMSO: 91 mg/mL (200.66 mM), clear; moisture-contaminated DMSO may reduce solubility—use fresh, anhydrous DMSO. Ethanol: 22 mg/mL. Water: Insoluble

• Appearance: White to beige crystalline powder; melting point: ~158-162°C

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.