MK-677 (Ibutamoren Mesylate) – Powder, 1g

MK-677 (Ibutamoren Mesylate) – Powder, 1g

This premium, laboratory-grade research compound delivers ultra-pure raw MK-677 (Ibutamoren Mesylate) powder at ≥98% purity, representing the highest standard for modern scientific investigations into ghrelin receptor agonism and growth hormone secretion mechanisms. The lyophilized crystalline powder form provides investigators with a single-compound reference standard ideal for analytical testing, in vitro cell culture modeling of GHSR-mediated pathways, and in vivo preclinical research applications where precise MK-677 isolation is critical for studying GH/IGF-1 elevation and anabolic effects.

Marine shipments to the 50 United States are fulfilled directly from primary U.S. production facilities, ensuring 2-5 business day delivery nationwide. International orders to the United Kingdom and continental Europe are processed through our dedicated United Kingdom shipping hub, which streamlines customs clearance and reduces transit times across all European countries. This dual-hub logistics infrastructure guarantees seamless, compliant delivery while maintaining chemical integrity throughout transit.

• Public third-party lab reports with unique lot-coding ensure absolute transparency for every batch sold

• Formulation contains zero flow agents, excipients, or adulterants—pure MK-677 only

• Strategic over-weighing compensates for powder adhesion loss, guaranteeing minimum 1g recoverable material

• Amber glass bottle features UV-resistant construction and tamper-proof seal for transit safety

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

GHSR Agonism & GH/IGF-1 Elevation Profiling

Ibutamoren (INN; developmental code MK-677, MK-0677, LUM-201, L-163,191; former tentative brand name Oratrope) functions as a potent, long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. The compound is a small molecule that stimulates the production of human growth hormone (hGH) and insulin-like growth factor 1 (IGF-1), with effects similar to peptides that increase hGH levels, but MK-677 can be taken orally as a powder, tablet, or liquid, whereas peptides need to be injected. MK-677 claims to promote muscle growth, better sleep and enhanced recovery through increased hGH and IGF-1 levels that cause changes in body composition, such as muscle growth, but these gains aren’t permanent, and effects wear off when people stop taking the drug. In conclusion, MK-677 reverses diet-induced nitrogen wasting, suggesting that if these short-term anabolic effects are maintained in patients who are catabolic because of certain acute or chronic disease states, it may be useful in treating catabolic conditions, demonstrating its potential for frailty and growth hormone deficiency research. Researchers stopped at least one clinical trial of MK-677 early because of concerns that it might cause heart failure, and the FDA lists Ibutamoren as an ingredient that “poses significant safety risks due to the potential for congestive heart failure in certain patients”. Many studies show diabetes-like impacts of MK-677 including increases in blood glucose levels, reductions in insulin sensitivity and increases in glycated haemoglobin (HbA1c), and it can also affect bone mineral density, representing significant health risks associated with use. MK-677 has been around since the mid-1990s, but it’s still considered an experimental drug, with researchers trialing it for treating frailty in older people and children with growth hormone deficiency, but there are no approved uses for the drug in Australia, and MK-677 is banned in sport. MK-677 is on the DoD Prohibited Dietary Supplement Ingredients List and the World Anti-Doping Agency Prohibited List, is not legal for use, and is detectable in blood samples and urine tests with a detection window varying depending on dosage, duration of use and metabolism but can be up to several weeks. Other side effects include anxiety, diarrhea, increased fluid retention and swelling, increased hunger, muscle or joint pain, numbness, and nausea, and when combined with SARMs, MK-677 could negatively impact serum lipids, liver enzymes, testosterone levels, or worse. MK-677 has anabolic effects, but it is not technically classified as an anabolic steroid or SARM, and the health effects of long-term use have not been investigated and should not be assumed to be safe. This GHSR agonist mechanism positions MK-677 as a critical tool compound for investigating GH/IGF-1 elevation research, muscle growth mechanisms, body composition studies, frailty in older people models, growth hormone deficiency research, nitrogen wasting reversal, catabolic conditions treatment, and anabolic effects in preclinical models, though with significant safety concerns that limit therapeutic potential.

Handling & Storage Guidelines

• Long-Term Storage: Store at 2-8°C (39°F) for optimal stability (up to 2 years); stable at room temperature for short-term storage. Minimize open air exposure; store in a cool, dry place in airtight conditions away from direct sunlight to maximize shelf life; protect from light and moisture; amber glass bottle provides moisture barrier and UV resistance

• Solubility: H₂O: 5 mg/mL, clear; DMSO: soluble; Ethanol: soluble; DMF: soluble; for in vivo studies: appropriate vehicle formulation recommended

• Appearance: White to off-white crystalline powder; clear solutions in water, DMSO, ethanol, and DMF when properly dissolved

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.