GW0742 – Solution, 600mg (20mg/mL)

GW0742 – Solution, 600mg (20mg/mL)

This premium, laboratory-grade research compound delivers ultra-pure GW0742 solution at 20mg/mL concentration, representing the highest standard for modern scientific investigations into PPARδ/β receptor activation and metabolic regulation mechanisms. The ready-to-use solution format eliminates preparation time and ensures precise dosing accuracy for in vivo animal studies, eliminating solubility variability (GW0742 is insoluble in water) and providing investigators with a validated vehicle system ideal for analytical testing, pharmacokinetic modeling, and in vivo preclinical research applications where precise GW0742 administration is critical for studying lipid metabolism enhancement, fatty acid oxidation, and glucose homeostasis.

All shipments to the 50 United States are fulfilled directly from primary U.S. production facilities, ensuring 2-5 business day delivery nationwide. International orders to the United Kingdom and continental Europe are processed through our dedicated United Kingdom shipping hub, which streamlines customs clearance and reduces transit times across all European countries. This dual-hub logistics infrastructure guarantees seamless, compliant delivery while maintaining chemical integrity throughout transit.

• Public third-party lab reports with unique lot-coding ensure absolute transparency for every batch sold

• Formulation contains zero adulterants, excipients, flow agents, or contaminants—pure GW0742 solution only

• Strategic over-fill compensates for solution adhesion loss, guaranteeing minimum 30mL (600mg) recoverable volume

• Amber glass bottle features UV-resistant construction and tamper-proof seal for transit safety

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

PPARδ Agonism & Lipid Metabolism Enhancement Profiling

GW0742 (GW-0742, GW610742, Fitorine) functions as a potent PPARβ and PPARδ agonist with an IC₅₀ of 1 nM for human PPARδ in binding assays, and EC₅₀ values of 1 nM, 1.1 μM, and 2 μM for human PPARδ, PPARα, and PPARγ, respectively, demonstrating approximately 1000-fold selectivity for PPARδ. The compound is a selective agonist of PPARδ with an EC₅₀ value of 1.1 nM, ideal for cancer research and epigenetic studies, and modulates lipid metabolism and energy homeostasis, applied in metabolic and cardiovascular research. GW0742 functions as a dual PPAR-β agonist and antagonist depending on the dosage administered, with antagonistic effects at androgen receptors and vitamin D receptor (VDR), and weak activity on multiple nuclear receptors. The compound has been shown to ameliorate experimentally induced pancreatitis in mice, demonstrating therapeutic potential for inflammatory conditions. Additionally, GW0742 prevents hypertension in diet-induced obese mice, has been investigated as a potential antidiabetic drug, exhibits anti-inflammatory effects, increases HDL cholesterol, and promotes orange adipose tissue browning, contributing to improved metabolic health. GW0742 has been shown to reverse metabolic abnormalities in obese men and may provide extreme increases in endurance and recovery, with rapid and effective fat loss. The compound is a promising candidate to enhance liver metabolism, reduce liver stress, act as an anti-inflammatory agent, and normalize insulin sensitivity. This PPARδ agonist mechanism positions GW0742 solution as a critical tool compound for investigating obesity research, metabolic syndrome studies, diabetes mechanisms, cardiovascular disease pathways, inflammation research, pancreatitis models, hypertension in obese populations, and lipid metabolism regulation in preclinical models, offering potential therapeutic insights for metabolic disorders.

Handling & Storage Guidelines

• Long-Term Storage: Store at room temperature (15-25°C) in a cool, dry place away from direct sunlight to maintain potency and maximize shelf life (up to 2 years). UV-resistant glass bottle minimizes degradation; tamper-proof seal ensures secure delivery. Avoid excessive heat and moisture; do not recommend long-term storage for solutions—use promptly after opening

• Solubility: Pre-dissolved formulation ready for direct use; DMSO: 250 mg/mL (530 mM), sonication recommended; Ethanol: ≥49.7 mg/mL with gentle warming and ultrasound; Water: insoluble; In Vivo formulation: 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline at 2 mg/mL; shake/agitate bottle before each administration for consistency

• Appearance: Clear colorless to pale yellow liquid solution; 30mL volume containing 600mg total GW0742 at 20mg/mL concentration; <5% concentration variance for consistency

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.