LGD-4033 (Ligandrol) – Powder, 1g

LGD-4033 (Ligandrol) – Powder, 1g

This premium, laboratory-grade research compound delivers ultra-pure raw LGD-4033 (Ligandrol) powder at ≥98% purity, representing the highest standard for modern scientific investigations into selective androgen receptor modulation and anabolic signaling mechanisms in muscle and bone. The lyophilized crystalline powder form provides investigators with a single-compound reference standard ideal for analytical testing, in vitro cell culture modeling of AR-mediated pathways, and in vivo preclinical research applications where precise LGD-4033 isolation is critical for studying muscle atrophy prevention, bone density enhancement, and tissue-selective androgenic effects.

All shipments to the 50 United States are fulfilled directly from primary U.S. production facilities, ensuring 2-5 business day delivery nationwide. International orders to the United Kingdom and continental Europe are processed through our dedicated United Kingdom shipping hub, which streamlines customs clearance and reduces transit times across all European countries. This dual-hub logistics infrastructure guarantees seamless, compliant delivery while maintaining chemical integrity throughout transit.

• Public third-party lab reports with unique lot-coding ensure absolute transparency for every batch sold

• Formulation contains zero flow agents, excipients, or adulterants—pure LGD-4033 only

• Strategic over-weighing compensates for powder adhesion loss, guaranteeing minimum 1g recoverable material

• PET single-wall jar features UV-resistant construction and tamper-proof seal for transit safety

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

SARM-Mediated AR Agonism & Muscle/Bone Enhancement Profiling

LGD-4033 (also known as VK-5211 and Ligandrol) functions as a novel, potent and selective androgen receptor modulator (SARM) developed by Ligand Pharmaceuticals, being investigated for treatment of conditions such as muscle wasting and osteoporosis. The compound is a third-generation non-steroidal oral SARM that possesses a strong affinity for the androgen receptor, with a Ki of approximately 1 nM, ranking as the second most sought-after SARM in the market today. Unlike testosterone, which produces anabolic effects via the same pathway, LGD-4033 selectively binds to receptors in skeletal muscle, bone, and connective tissue, with very little affinity for receptors in the prostate, scalp, and skin, demonstrating tissue-selective activation of androgenic signaling. LGD-4033 functions through selective binding and activation of the androgen receptor, and by selectively targeting androgen receptors in muscle and bone tissues, it promotes anabolic activity without significantly impacting androgenic organs like the prostate. Its tissue-selective mechanism of action has the potential to prevent muscle wasting, promote muscle growth, and enhance bone mineral density, addressing muscle atrophy and osteoporosis without the virilizing consequences that come with anabolic steroids. The compound was safe in clinical studies and had a favorable pharmacokinetic profile, with a half-life of 24-36 hours, making it suitable for oral administration. LGD-4033 increases lean body mass, increases nitrogen retention, stimulates lipolysis (fat breakdown), and enhances bone density, demonstrating comprehensive anabolic effects for muscle and bone health. This SARM mechanism positions LGD-4033 as a critical tool compound for investigating muscle atrophy prevention research, osteoporosis treatment models, lean body mass preservation studies, bone mineral density enhancement pathways, nitrogen retention mechanisms, lipolysis stimulation, and tissue-selective androgen receptor signaling in preclinical models, offering potential therapeutic insights for metabolic and musculoskeletal disorders.

Handling & Storage Guidelines

• Long-Term Storage: Powder: Store at -20°C (-4°F) for optimal stability (up to 3 years); stable at 4°C (39°F) for 2 years; stable at room temperature for a few days during ordinary shipping and time spent in Customs. Minimize open air exposure; store in a cool, dry place in airtight conditions away from direct sunlight to maximize shelf life; protect from light and moisture; double-sealed Mylar bag or PET single-wall jar provides moisture barrier and UV resistance

• Solubility: May dissolve in DMSO (in most cases); if not soluble in DMSO, try other solvents such as H₂O, Ethanol, or DMF with a minute amount of products to avoid loss of samples; water solubility low; for in vivo studies: appropriate vehicle formulation recommended

• Appearance: White to off-white crystalline powder; typically exists as solid at room temperature; clear solutions in DMSO, ethanol, and DMF when properly dissolved

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.