Adipotide – Aliquot, 5mg

Adipotide – Aliquot, 5mg

This premium, laboratory-grade research compound delivers ultra-pure synthetic Adipotide peptidomimetic at 99% purity, representing the highest standard for modern scientific investigations into adipose tissue vasculature targeting and metabolic remodeling mechanisms. The lyophilized aliquot format provides investigators with a ready-to-reconstitute single-compound reference standard ideal for analytical testing, in vitro cell culture modeling of adipose endothelial cells, and in vivo preclinical research applications where precise adipotide administration is critical for studying targeted apoptosis of white fat blood vessels and subsequent weight loss without systemic toxicity.

All shipments to the 50 United States are fulfilled directly from primary U.S. production facilities, ensuring 2-5 business day delivery nationwide. International orders to the United Kingdom and continental Europe are processed through our dedicated United Kingdom shipping hub, which streamlines customs clearance and reduces transit times across all European countries. This dual-hub logistics infrastructure guarantees seamless, compliant delivery while maintaining peptide integrity throughout transit.

• Public third-party lab reports with unique lot-coding ensure absolute transparency for every batch sold

• Formulation contains zero adulterants, excipients, flow agents, or contaminants—pure Adipotide peptide only

• Strategic over-packaging compensates for peptide adhesion loss, guaranteeing minimum 5mg recoverable material

• Lyophilized vial features UV-resistant construction and tamper-proof seal for transit safety

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

Prohibitin-Targeted Adipose Vasculature Apoptosis & Metabolic Remodeling Profile

Adipotide functions as a synthetic dual-function chimeric peptidomimetic consisting of two distinct functional domains: the CKGGRAKDC homing domain that binds prohibitin (a protein overexpressed on endothelial cells of white adipose tissue blood vessels) and the proapoptotic D(KLAKLAK)₂ sequence that induces mitochondria-mediated apoptosis upon cellular internalization. This targeted mechanism results in selective endothelial cell apoptosis within adipose vasculature while showing minimal apoptosis in other tissues, demonstrating remarkable tissue specificity. In obese rodent models, treatment with adipotide induced targeted apoptosis within blood vessels of white adipose tissue and resulted in rapid weight loss of up to 30% body weight after only 28 days of treatment, accompanied by improved insulin sensitivity and metabolic parameters. The compound disrupts the blood supply to white fat cells, causing them to be reabsorbed and metabolized without affecting brown adipose tissue, confirming its selectivity for white fat vasculature. Adipotide was investigated in Phase 1 clinical trials for castrate-resistant prostate cancer patients, with dosing administered as subcutaneous injection once daily for 28 days across five dose levels to identify maximum tolerated dose and assess pharmacokinetics. This tissue-selective mechanism positions Adipotide as a critical tool compound for investigating obesity mechanisms, metabolic syndrome research, insulin resistance pathways, adipose tissue remodeling studies, and anti-obesity therapeutic development in preclinical models, offering potential therapeutic benefits for weight management without systemic toxicity.

Handling & Storage Guidelines

• Long-Term Storage: Keep lyophilized peptide sealed in original vial, protected from light and humidity; store at -20°C (-4°F) or colder for optimal long-term stability (up to 3 years); short-term storage at 2-8°C (39°F) suffices for immediate use within weeks

• Solubility: Reconstitute in sterile water or PBS (1-5 mg/mL); soluble in DMSO (10 mg/mL); avoid repeated freeze-thaw cycles; add 0.1% BSA to improve stability for in vivo studies

• Appearance: Lyophilized white to off-white powder; reconstituted solution is clear and colorless

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.