SR9011 – Powder, 1g

SR9011 represents a premium, laboratory-grade investigational second-generation Rev-erbα/β agonist delivered in ultra-pure crystalline solid powder form at 1g quantity. This high-purity raw chemical material provides exceptional technical value to modern scientific investigations focused on circadian biology, metabolic disorder research, lipid metabolism analysis, cancer cell research, and cardiovascular preclinical studies. The crystalline solid powder format ensures maximum stability and precise reconstitution accuracy for analytical testing and in vitro/in vivo modeling applications conducted by qualified investigators studying metabolic pathways and circadian rhythm disruption.

Our global shipping infrastructure ensures seamless delivery to research facilities worldwide. Domestic orders within the United States ship directly from primary U.S. production facilities, ensuring rapid fulfillment across all 50 states. International orders, including all European countries, utilize our dedicated United Kingdom shipping hub to ensure seamless, efficient customs clearance across the UK and continental Europe, minimizing transit delays while maintaining chemical stability throughout shipment.

• Unique lot-coding on every vessel with public third-party HPLC and mass spectrometry lab reports available for absolute transparency and quality verification

• Formulation completely free of adulterants, excipients, flow agents, or stabilizers to guarantee unadulterated raw chemical purity for accurate research data

• Strategic precision over-weighing inside the vessel compensates for natural adhesion loss during laboratory transfer, ensuring investigators receive minimum labeled quantity

• Packaging engineering utilizes UV-resistant sealing with tamper-proof closure designed specifically for transit safety and structural integrity during international shipment

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

Second-Generation Rev-erbα/β Agonist Activity & Circadian-Metabolic Pathway Regulation

SR9011 functions as a potent second-generation synthetic agonist of the nuclear receptors REV-ERBα and REV-ERBβ (also known as NR1D1 and NR1D2), which are core clock components linking circadian rhythms to metabolic regulation. The compound increases the constitutive repression of genes regulated by REV-ERBα and REV-ERBβ with IC50 values of 790 nM and 560 nM respectively, demonstrating higher potency at REV-ERBβ than SR9009. SR9011 suppresses BMAL1 mRNA expression in HepG2 cells in a REV-ERBα/β-dependent manner and alters the circadian pattern of expression of several metabolic genes in liver, skeletal muscle, and adipose tissue of mice, resulting in increased energy expenditure. As a second-generation activator of Rev-ErbA receptors found abundantly in liver, skeletal muscle, fat tissue, and the brain, SR9011 has demonstrated anti-cancer effects and is specifically lethal to cancer cells and oncogene-induced senescent cells. Research applications include circadian rhythm disruption modeling, metabolic syndrome research, lipid metabolism studies, microglial immune-metabolism investigations, cancer research, obesity research, and cardiovascular function improvement.

Handling & Storage Guidelines

• Long-Term Storage: Store powder at -20°C for up to 3 years, or at -80°C for 1 year in solvent. Minimize open air exposure, store in a cool, dry place protected from moisture and light.

• Solubility: Highly soluble in DMSO (≥47.9 mg/mL, 50 mg/mL or 104.38 mM). Sonication is recommended. For in vivo preparation: 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline at 2 mg/mL.

• Appearance: Crystalline solid powder, white to off-white form.

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.