Racemic Tesofensine – Solution, 30mg (1mg/mL)

Racemic Tesofensine – Solution, 30mg (1mg/mL)

This premium, laboratory-grade research compound delivers ultra-pure racemic tesofensine solution at 1mg/mL concentration, representing the highest standard for modern scientific investigations into triple monoamine reuptake inhibition and anti-obesity mechanisms. The ready-to-use solution format eliminates preparation time and ensures precise dosing accuracy for in vivo animal studies, eliminating solubility variability and providing investigators with a validated vehicle system ideal for analytical testing, pharmacokinetic modeling, and in vivo preclinical research applications where precise tesofensine administration is critical for studying metabolic regulation, appetite suppression, and weight management pathways.

All shipments to the 50 United States are fulfilled directly from primary U.S. production facilities, ensuring 2-5 business day delivery nationwide. International orders to the United Kingdom and continental Europe are processed through our dedicated United Kingdom shipping hub, which streamlines customs clearance and reduces transit times across all European countries. This dual-hub logistics infrastructure guarantees seamless, compliant delivery while maintaining chemical integrity throughout transit.

• Public third-party lab reports with unique lot-coding ensure absolute transparency for every batch sold

• Formulation contains zero flow agents, excipients, or adulterants—pure racemic tesofensine solution only

• Strategic over-fill compensates for solution adhesion loss, guaranteeing minimum 30mL (30mg) recoverable volume

• Amber glass bottle features UV-resistant construction and tamper-proof seal for transit safety

Technical Specifications & Chemical Profile

Research Applications & Storage Protocols

SNDRI-Mediated Appetite Suppression & Weight Loss Profiling

Tesofensine (NS2330, NS-2330) functions as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) from the phenyltropane family of drugs, which is being developed for the treatment of obesity. The compound is a triple monoamine reuptake inhibitor inducing potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC₅₀ = 6.5 nM), norepinephrine (NE; IC₅₀ = 1.7 nM), and serotonin (5-HT; IC₅₀ = 11 nM), demonstrating high potency for all three monoamine transporters. Tesofensine primarily acts as an appetite suppressant, but possibly also acts by increasing resting energy expenditure, providing dual mechanisms for weight loss. In vivo, tesofensine (2 mg/kg, s.c.) reduces body weight and food intake in a rat model of high-fat diet-induced obesity, confirming its efficacy in animal models. Initially developed by NeuroSearch for treating Alzheimer’s and Parkinson’s diseases, researchers discovered significant weight loss as a side effect during clinical trials, demonstrating the compound’s unexpected anti-obesity properties. As of 2019, tesofensine has been discontinued for the treatment of Alzheimer’s and Parkinson’s disease but is in phase III clinical trial for obesity, confirming its therapeutic pivot to weight management. Patients lost an average of 12.8 kg on the 1 mg dose, 11.3 kg on the 0.5 mg dose, and 6.7 kg on the 0.25 mg dose, compared with a 2.2 kg loss in the placebo group, demonstrating dose-dependent weight loss efficacy in clinical trials. In general, the safety profile of tesofensine is similar to currently approved medications for the treatment of obesity, with commonly reported side effects including dry mouth, headache, nausea, insomnia, diarrhea, and constipation. A dose-dependent pattern was observed for dry mouth and insomnia, and the overall withdrawal rate due to adverse events in clinical trials in the obese population was 13% with tesofensine and 6% with placebo. At the conclusion of phase II clinical trials, Saniona announced that tesofensine was well tolerated with low incidence of adverse events, low increase in heart rate, and no significant effect on blood pressure, confirming favorable safety profile. Tesofensine is a triple monoamine reuptake inhibitor that inhibits norepinephrine, serotonin (5-HT), and dopamine reuptake function, demonstrating comprehensive SNDRI mechanism of action. This SNDRI mechanism positions racemic tesofensine solution as a critical tool compound for investigating metabolic syndrome research, weight regulation studies, neurochemical balance analysis, appetite control mechanisms, energy expenditure analysis, behavioral and cognitive function models, and weight management pathways in preclinical models, offering potential therapeutic insights for obesity treatment with favorable safety profile.

Handling & Storage Guidelines

• Long-Term Storage: Store at 20°C (room temperature) in a sealed container, away from light and moisture to maintain potency. Keep out of direct sunlight; tamper-proof seal ensures secure delivery. Handle at room temperature; avoid excessive heat and moisture; do not recommend long-term storage for aqueous solutions—use promptly after opening

• Solubility: Pre-dissolved formulation ready for direct use; Soluble in DMSO (~1 mg/mL); Soluble in dimethyl formamide (~2 mg/mL); Slightly soluble in ethanol; Soluble in PBS (pH 7.2) at ~0.14 mg/mL; aqueous solutions should not be stored for more than one day; shake/agitate bottle before each administration for consistency

• Appearance: Clear liquid solution; 30mL volume containing 30mg total racemic tesofensine at 1mg/mL concentration; <5% concentration variance for consistency

Global Logistics & Order Fulfillment

We proudly support scientific advancement across all 50 U.S. states and throughout Europe. Customers can seamlessly toggle their preferred currency between USD and EUR using the currency switcher located on the left-hand side of our website. All shipments are securely packaged to withstand international transit without compromising structural or chemical stability.

Laboratory Use Only Disclaimer

This material is sold strictly for laboratory research and development use only. It is not approved for human consumption, nor for medical, veterinary, or household applications. All purchases are governed by our standard Terms & Conditions. Please review them carefully before placing your order.